Biological Effects of Chitosan-Based Dressing on Hemostasis Mechanism
| Autor: | Yi-Wen Wang, Cheng-Che Liu, Yaw-Kwan Chiu, And Hung Chang, Chien-Seng Lin, Zhi-Jie Hong, Chuan-Chieh Liu, Sheng-Der Hsu, Shu-Jen Chang, Juin-Hong Cherng |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Prolonged Partial Thromboplastin Time
Polymers and Plastics 02 engineering and technology Femoral artery Article Chitosan lcsh:QD241-441 03 medical and health sciences chemistry.chemical_compound Wound care lcsh:Organic chemistry medicine.artery Medicine coagulation factor 030304 developmental biology chitosan dressing 0303 health sciences integumentary system business.industry Antithrombin Surgical wound General Chemistry 021001 nanoscience & nanotechnology equipment and supplies antithrombin chemistry Coagulation Anesthesia Hemostasis hemostasis hemorrhage 0210 nano-technology business human activities medicine.drug |
| Zdroj: | Polymers, Vol 11, Iss 11, p 1906 (2019) Polymers Volume 11 Issue 11 |
| ISSN: | 2073-4360 |
| Popis: | There have been numerous recent advances in wound care management. Nevertheless, the assessment of hemostatic dressing is essential to enable surgeons and other physicians and healthcare professionals to make the correct decisions regarding the disposition of severe hemorrhage. Here, we investigated the relative efficacies of chitosan-based and conventional gauze dressings in a rat model of femoral artery hemorrhage and in patients with surgical wounds. Dressing effectiveness was evaluated based on hemostatic profiles, biocompatibility, antimicrobial activity, and blood factor responses in coagulation. Relative to standard gauze dressing, the chitosan fiber (CF) dressing treatment significantly shortened the time to hemostasis in injured rats. Moreover, the CF dressing significantly prolonged partial thromboplastin time, enhanced blood absorption, and reduced antithrombin production without altering the prothrombin ratio. Unlike regular gauze bandages, the CF dressing demonstrated remarkable antibacterial activity. The results of this study indicate the effectiveness of chitosan as a hemostatic dressing and elucidate its underlying mechanism. It is possible that chitosan surgical dressings could serve as first-line intervention in hospital emergency care for uncontrolled hemorrhage. |
| Databáze: | OpenAIRE |
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