TRANSCompel(R): a database on composite regulatory elements in eukaryotic genes
Autor: | Igor Deineko, Alexander E. Kel, Olga V. Kel-Margoulis, Edgar Wingender, Ingmar Reuter |
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Rok vydání: | 2002 |
Předmět: |
Transcriptional Activation
Transcription Genetic Macromolecular Substances Information Storage and Retrieval Regulatory Sequences Nucleic Acid Biology computer.software_genre Article DNA sequencing chemistry.chemical_compound Genetics Transcriptional regulation Animals Humans Binding site Promoter Regions Genetic Gene Transcription factor Regulation of gene expression Internet Binding Sites Database Systems Integration nucleic acids Eukaryotic Cells chemistry Databases Nucleic Acid computer Function (biology) DNA Transcription Factors |
Zdroj: | Nucleic Acids Research. 30:332-334 |
ISSN: | 1362-4962 |
Popis: | Originating from COMPEL, the TRANSCompel® database emphasizes the key role of specific interactions between transcription factors binding to their target sites providing specific features of gene regulation in a particular cellular content. Composite regulatory elements contain two closely situated binding sites for distinct transcription factors and represent minimal functional units providing combinatorial transcriptional regulation. Both specific factor–DNA and factor–factor interactions contribute to the function of composite elements (CEs). Information about the structure of known CEs and specific gene regulation achieved through such CEs appears to be extremely useful for promoter prediction, for gene function prediction and for applied gene engineering as well. Each database entry corresponds to an individual CE within a particular gene and contains information about two binding sites, two corresponding transcription factors and experiments confirming cooperative action between transcription factors. The COMPEL database, equipped with the search and browse tools, is available at http://www.gene-regulation.com/pub/databases.html#transcompel. Moreover, we have developed the program CATCHTM for searching potential CEs in DNA sequences. It is freely available as CompelPatternSearch at http://compel.bionet.nsc.ru/FunSite/CompelPatternSearch.html peerReviewed |
Databáze: | OpenAIRE |
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