Distribution of c-Fos immunoreactivity in the rat brain following abuse-like toluene vapor inhalation
| Autor: | Caleb J. Browne, Brittany A. Matthews, Tanya Raaphorst, Kristina E. Perit, Bruce E. McKay, Jimmie M. Gmaz, Paul E. Mallet, Linda Yang, Mary Beth F. Dunn |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Cingulate cortex
Male Inhalant Abuse Nucleus accumbens Toxicology Amygdala Rats Sprague-Dawley Cellular and Molecular Neuroscience Developmental Neuroscience Piriform cortex Administration Inhalation medicine Animals Behavior Animal Chemistry Brain Immunohistochemistry Pons Rats Ventral tegmental area Disease Models Animal medicine.anatomical_structure Forebrain Acute Disease Solvents Brainstem Neuroscience Proto-Oncogene Proteins c-fos Biomarkers Toluene |
| Zdroj: | Neurotoxicology and teratology. 34(1) |
| ISSN: | 1872-9738 |
| Popis: | Inhalation of vapors from toluene-containing products results in euphoria accompanied by a variety of cognitive impairments and motor dysfunctions. The profound behavioral changes observed during and following toluene inhalation suggest changes in the activity of cells in potentially many brain regions; however, a comprehensive assessment of the neuroanatomical structures activated by toluene vapor has not been completed. Thus in the present study we systematically mapped in over 140 brain structures the distribution of c-Fos immunoreactivity (c-Fos IR), a proxy for neural activation, following exposure to an abuse-like concentration (~ 5000 ppm) of toluene vapor for 0, 5, 10 or 30 min. Quantitative analyses revealed increases in c-Fos IR in about one-third of the brain structures examined, with most of these structures significantly activated only after prolonged toluene exposure. The majority of brain structures activated by toluene were found in the forebrain and midbrain, with particularly pronounced activation in nuclei implicated in the processing of rewarding, emotional, and olfactory stimuli, and those controlling motor output. These structures included the ventral tegmental area, nucleus accumbens, select regions of the amygdala and hypothalamus, cingulate cortex, olfactory nuclei, piriform cortex, secondary motor cortex and caudate-putamen. In contrast, all subregions of the hippocampus and most thalamic nuclei were not significantly activated by toluene vapor. In the brainstem, effects of toluene vapor were restricted to select nuclei in the pons. The pattern of c-Fos IR evoked by inhalation of toluene vapor appears distinct from other psychoactive substances, consistent with the unique and complex behavioral outcomes associated with acute toluene inhalation. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect