Zeolite-embedded silver extends antimicrobial activity of dental acrylics
| Autor: | Sheela Rai, James Pritchett, Joanna Verran, Lubomira Tosheva, James Redfern, Christopher M. Liauw, Sladjana Malic |
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| Rok vydání: | 2018 |
| Předmět: |
Staphylococcus aureus
Silver Acrylic Resins Oral Microflora 02 engineering and technology 01 natural sciences Streptococcus mutans Dental Materials Colloid and Surface Chemistry Anti-Infective Agents 0103 physical sciences Candida albicans Humans Physical and Theoretical Chemistry Zeolite Dentures 010304 chemical physics biology Fusobacterium nucleatum Chemistry Surfaces and Interfaces General Medicine 021001 nanoscience & nanotechnology biology.organism_classification Antimicrobial Drug Liberation Kinetics Distilled water Delayed-Action Preparations Zeolites Leaching (metallurgy) 0210 nano-technology Biotechnology Nuclear chemistry |
| Zdroj: | Colloids and surfaces. B, Biointerfaces. 173 |
| ISSN: | 1873-4367 |
| Popis: | The insertion of prosthetic devices into the oral cavity affects the oral microflora and results in accumulation of microorganisms on the prosthetic surface. Such fouling of denture surfaces can lead to a number of oral diseases and consequently to the replacement of the denture. Here, we report the post-synthesis introduction of silver in zeolite-loaded dental acrylic (DAZ) resins that does not influence the mechanical or aesthetic properties of the DA resins, and provides them with a long-term antimicrobial activity. Na-FAU zeolite (2 wt%) was incorporated into DA resin, which was conventionally processed and cut into 10 mm × 20 mm × 3 mm coupons. The Na+ in the zeolite was then exchanged with Ag+ via immersion of the DAZ coupons in 0.01 M AgNO3 solution to obtain DAZ/Ag-treated coupons used in antimicrobial tests. Antimicrobial tests showed that the DAZ/Ag-treated coupons were active against Candida albicans (a reference and a clinically relevant strain), Streptococcus mutans and Fusobacterium nucleatum. Ag leaching tests on the Ag-charged coupons at 1, 2, 3, 4, 7, 14, 30 and 45 days of incubation in distilled water at 37 °C, indicated sustained release of silver. Antimicrobial tests using a reference Candida albicans strain showed that the leached coupons retained antimicrobial activity after 45 days immersion in distilled water, but, after 60 days incubation no antimicrobial activity was observed. Cytotoxicity assay results indicated that the DAZ/Ag-treated coupons showed no additional cytotoxicity compared to neat dental acrylic coupons. |
| Databáze: | OpenAIRE |
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