In the Search of Glycoside-Based Molecules as Antidiabetic Agents
| Autor: | Bartłomiej Bazan, Dariusz Cież, Aleksandra Pałasz, Bartosz Trzewik, Katarzyna Miszczak, Grzegorz Tynor |
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| Rok vydání: | 2018 |
| Předmět: |
C glycosides
Computational biology Review 010402 general chemistry 01 natural sciences Ranking (information retrieval) Structure-Activity Relationship Drug Discovery Diabetes type 2 Diabetes Mellitus Animals Humans Hypoglycemic Agents Glycosides Enzyme Inhibitors Sodium-Glucose Transporter 2 Inhibitors Antidiabetic agents chemistry.chemical_classification Protein Tyrosine Phosphatase Non-Receptor Type 1 Biological studies Chemistry Drug discovery Sodium-dependent glucose cotransporter inhibitor Glycogen Phosphorylase C-Glycosides Glycoside General Chemistry N-Glycosides 0104 chemical sciences Glycogen phosphorylase inhibitor O-Glycosides |
| Zdroj: | Topics in Current Chemistry (Cham) |
| ISSN: | 2364-8961 |
| Popis: | This review is an effort to summarize recent developments in synthesis of O-glycosides and N-, C-glycosyl molecules with promising antidiabetic potential. Articles published after 2000 are included. First, the O-glycosides used in the treatment of diabetes are presented, followed by the N-glycosides and finally the C-glycosides constituting the largest group of antidiabetic drugs are described. Within each group of glycosides, we presented how the structure of compounds representing potential drugs changes and when discussing chemical compounds of a similar structure, achievements are presented in the chronological order. C-Glycosyl compounds mimicking O-glycosides structure, exhibit the best features in terms of pharmacodynamics and pharmacokinetics. Therefore, the largest part of the article is concerned with the description of the synthesis and biological studies of various C-glycosides. Also N-glycosides such as N-(β-d-glucopyranosyl)-amides, N-(β-d-glucopyranosyl)-ureas, and 1,2,3-triazolyl derivatives belong to the most potent classes of antidiabetic agents. In order to indicate which of the compounds presented in the given sections have the best inhibitory properties, a list of the best inhibitors is presented at the end of each section. In summary, the best inhibitors were selected from each of the summarizing figures and the results of the ranking were placed. In this way, the reader can learn about the structure of the compounds having the best antidiabetic activity. The compounds, whose synthesis was described in the article but did not appear on the figures presenting the structures of the most active inhibitors, did not show proper activity as inhibitors. Thus, the article also presents studies that have not yielded the desired results and show directions of research that should not be followed. In order to show the directions of the latest research, articles from 2018 to 2019 are described in a separate Sect. 5. In Sect. 6, biological mechanisms of action of the glycosides and patents of marketed drugs are described. |
| Databáze: | OpenAIRE |
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