Elevated serum levels of TNF-α, IL-8, and ECP can be involved in the development and progression of bronchial asthma
| Autor: | Peng-Hui Zhuang, Xiao-Gang Jiang, Xudong Yang, Zhe Lv |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Pulmonary and Respiratory Medicine Adult Male Vital Capacity Elevated serum 03 medical and health sciences 0302 clinical medicine Forced Expiratory Volume medicine Immunology and Allergy Humans Interleukin 8 Tumor necrosis factor α Asthma Eosinophil cationic protein business.industry Tumor Necrosis Factor-alpha Eosinophil Cationic Protein Interleukin-8 respiratory system Middle Aged medicine.disease 030104 developmental biology 030228 respiratory system ROC Curve Pediatrics Perinatology and Child Health Immunology Tumor necrosis factor alpha Female business |
| Zdroj: | The Journal of asthma : official journal of the Association for the Care of Asthma. 55(2) |
| ISSN: | 1532-4303 |
| Popis: | This study aimed to explore the value of elevated serum levels of tumor necrosis factor-α (TNF-α), interleukin-8 (IL-8), and eosinophil cationic protein (ECP) in the diagnosis of bronchial asthma (BA).A total of 170 patients with BA (case group, 85 patients in acute attack and 85 patients in clinical remission) and 150 healthy individuals (control group) were enrolled in this study. Enzyme-linked immunosorbent assay and receiver operating characteristic (ROC) curves were calculated for the contents and diagnostic values of serum TNF-α, IL-8, and ECP in BA.Compared with the control group, patients in acute attack and clinical remission had higher TNF-α, IL-8, and ECP levels (p0.05). The serum level of TNF-α was positively correlated with IL-8 and ECP (p0.05). ROC curves showed that the diagnostic threshold value of IL-8 was 13.53 ng/ml, its area under the curve (AUC) was 0.87, its specificity was 99.3%, and its sensitivity was 57.6%. The diagnostic threshold value of TNF-α was 1.29 ng/ml with AUC being 0.94, specificity was 89.3%, and sensitivity was 83.5%. ECP showed 7.22 ng/ml diagnostic threshold value (AUC = 0.88, specificity = 74.0%, sensitivity = 86.5%). The FEVOur findings reveal that elevated serum levels of TNF-α, IL-8, and ECP can be involved in the development and progression of BA. |
| Databáze: | OpenAIRE |
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