Digital light 3D printing of customized bioresorbable airway stents with elastomeric properties
| Autor: | Ahmad Rafsanjani, Kunal Masania, Brigitte von Rechenberg, Fergal Coulter, Peter W Kronen, Agnieszka Karol, Davide Brambilla, Karina Klein, Zhi Luo, Jean-Christophe Leroux, André R. Studart, Daniel Franzen, Nicole Kleger, Jasmin Cadalbert, Fabienne Rüber, Yinyin Bao, Nevena Paunović, Anna Karoline Geks |
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| Přispěvatelé: | University of Zurich, Leroux, Jean-Christophe |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Biocompatibility
Polymers Materials Science 3D printing 610 Medicine & health 02 engineering and technology 010402 general chemistry 01 natural sciences chemistry.chemical_compound Engineering Silicone Absorbable Implants Tissue damage Animals Humans Medicine Central airway Research Articles Rapid manufacturing 1000 Multidisciplinary Multidisciplinary business.industry SciAdv r-articles 021001 nanoscience & nanotechnology Biocompatible material Elasticity 0104 chemical sciences chemistry Printing Three-Dimensional Stents Rabbits 10178 Clinic for Pneumology 0210 nano-technology Airway business Research Article Biomedical engineering |
| Zdroj: | Paunović, N, Bao, Y, Coulter, F B, Masania, K, Geks, A K, Klein, K, Rafsanjani, A, Cadalbert, J, Kronen, P W, Kleger, N, Karol, A, Luo, Z, Rüber, F, Brambilla, D, von Rechenberg, B, Franzen, D, Studart, A R & Leroux, J C 2021, ' Digital light 3D printing of customized bioresorbable airway stents with elastomeric properties ', Science Advances, vol. 7, no. 6, eabe9499 . https://doi.org/10.1126/sciadv.abe9499 Science Advances, 7 (6) Science Advances, 7(6) Science Advances |
| ISSN: | 2375-2548 |
| DOI: | 10.1126/sciadv.abe9499 |
| Popis: | Central airway obstruction is a life-threatening disorder causing a high physical and psychological burden to patients. Standard-of-care airway stents are silicone tubes, which provide immediate relief but are prone to migration. Thus, they require additional surgeries to be removed, which may cause tissue damage. Customized bioresorbable airway stents produced by 3D printing would be highly needed in the management of this disorder. However, biocompatible and biodegradable materials for 3D printing of elastic medical implants are still lacking. Here, we report dual-polymer photoinks for digital light 3D printing of customized and bioresorbable airway stents. These stents exhibit tunable elastomeric properties with suitable biodegradability. In vivo study in healthy rabbits confirmed biocompatibility and showed that the stents stayed in place for 7 weeks after which they became radiographically invisible. This work opens promising perspectives for the rapid manufacturing of the customized medical devices for which high precision, elasticity, and degradability are sought. Science Advances, 7 (6) ISSN:2375-2548 |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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