Factitious Hypoglycemia
Autor: | Petra M. Blix, John A. Scarlett, Jose Goldman, Jerrold M. Olefsky, Jonathan B. Jaspan, Arthur H. Rubenstein, Howard S. Tager, David L. Horwitz, Melvin R. Stjernholm, Mary E. Mako |
---|---|
Rok vydání: | 1977 |
Předmět: |
Adult
Male medicine.medical_specialty Adolescent Adenoma Substance-Related Disorders Insulin Antibodies medicine.medical_treatment Self Medication Diabetes Complications chemistry.chemical_compound Factitious hypoglycemia Internal medicine Diabetes mellitus medicine Humans Insulin C-Peptide biology C-peptide business.industry General Medicine Adenoma Islet Cell medicine.disease Antigen binding Hypoglycemia Pancreatic Neoplasms Titer Endocrinology chemistry Child Preschool biology.protein Female Antibody Peptides business |
Zdroj: | New England Journal of Medicine. 297:1029-1032 |
ISSN: | 1533-4406 0028-4793 |
DOI: | 10.1056/nejm197711102971903 |
Popis: | In seven patients with factitious hypoglycemia due to the surreptitious injection of insulin, we made the diagnosis by measurements of plasma insulin and C-peptide immunoreactivity (in seven patients), facilitated by the finding of circulating insulin-binding antibodies (in two patients). The simultaneous demonstration of low plasma glucose, high immunoreactive insulin and suppressed C-peptide immunoreactivity represents a triad of results pathognomonic of exogenous insulin administration. Determination of plasma free C-peptide and free insulin permitted patients with high titers of insulin antibodies, including those with a history of insulin-treated diabetes, to be studied and diagnosed in a way similar to that in subjects who had no circulating insulin antibodies. |
Databáze: | OpenAIRE |
Externí odkaz: |