Factitious Hypoglycemia

Autor: Petra M. Blix, John A. Scarlett, Jose Goldman, Jerrold M. Olefsky, Jonathan B. Jaspan, Arthur H. Rubenstein, Howard S. Tager, David L. Horwitz, Melvin R. Stjernholm, Mary E. Mako
Rok vydání: 1977
Předmět:
Zdroj: New England Journal of Medicine. 297:1029-1032
ISSN: 1533-4406
0028-4793
DOI: 10.1056/nejm197711102971903
Popis: In seven patients with factitious hypoglycemia due to the surreptitious injection of insulin, we made the diagnosis by measurements of plasma insulin and C-peptide immunoreactivity (in seven patients), facilitated by the finding of circulating insulin-binding antibodies (in two patients). The simultaneous demonstration of low plasma glucose, high immunoreactive insulin and suppressed C-peptide immunoreactivity represents a triad of results pathognomonic of exogenous insulin administration. Determination of plasma free C-peptide and free insulin permitted patients with high titers of insulin antibodies, including those with a history of insulin-treated diabetes, to be studied and diagnosed in a way similar to that in subjects who had no circulating insulin antibodies.
Databáze: OpenAIRE