Prognostic role of multiple biomarkers in stable patients undergoing fractional flow reserve-guided coronary angioplasty
| Autor: | Fracassi, F, Niccoli, G, Scalone, G, Di Gioia, G, Conte, M, Bartunek, J, Sgueglia, G. A, de Bruyne, B, Montone, R. A., Wijns, W., Crea, F., BARBATO, EMANUELE |
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| Přispěvatelé: | Fracassi, F, Niccoli, G, Scalone, G, Di Gioia, G, Conte, M, Bartunek, J, Sgueglia, G. A, De, Bruyne, B, Montone, R. A., Wijns, W., Crea, F., Barbato, Emanuele |
| Rok vydání: | 2016 |
| Předmět: |
Male
medicine.medical_specialty medicine.medical_treatment Fractional flow reserve 030204 cardiovascular system & hematology Coronary Angiography Risk Assessment Thromboxane A2 03 medical and health sciences 0302 clinical medicine Internal medicine Angioplasty Humans Medicine Prospective Studies cardiovascular diseases 030212 general & internal medicine Angioplasty Balloon Coronary Cystatin C Comparison of Right and Left Upper Limb Arterial Variants in Patients Undergoing Bilateral Transradial Procedures fractional flow reserve Prospective cohort study Aged biology business.industry percutaneous coronary intervention Eosinophil Cationic Protein C-reactive protein Coronary Stenosis biomarkers Percutaneous coronary intervention Stent General Medicine Middle Aged Prognosis medicine.disease Fractional Flow Reserve Myocardial Stenosis C-Reactive Protein Settore MED/11 - MALATTIE DELL'APPARATO CARDIOVASCOLARE Conventional PCI Disease Progression biology.protein Cardiology Female Stents Inflammation Mediators Cardiology and Cardiovascular Medicine business |
| Zdroj: | Journal of Cardiovascular Medicine. 17:687-693 |
| ISSN: | 1558-2027 |
| Popis: | AIMS: Fractional flow reserve (FFR)-guided percutaneous coronary intervention (PCI), along with optimal medical therapy, improves clinical outcome by targeting ischemia-inducing stenosis. Yet, plaque progression or stent failure may cause recurring cardiac events. We assessed the potential prognostic role of different inflammatory biomarkers, known to be associated with plaque progression or stent failure, in patients undergoing FFR-guided PCI. METHODS: We prospectively enrolled 169 stable angina patients with intermediate coronary stenosis at angiography undergoing FFR-guided PCI. PCI was performed if FFR was 0.80 or less, deferred if FFR was more than 0.80. Serum baseline levels of high-sensitivity C-reactive protein (hs-CRP), eosinophil cationic protein (ECP), cystatin-C (Cys-C), and thromboxane A2 (TXA2) were assessed. Rate of major adverse cardiovascular events (MACE), defined as a composite of cardiovascular death, recurrent myocardial infarction, and target vessel revascularization (TVR), was evaluated. RESULTS: PCI was performed in 78 patients (46%) (mean age 69?±?10 years, men 73%) and deferred in 91 patients (54%) (mean age 64?±?11 years, men 53%). Mean clinical follow-up was 31?±?11 months. Within the PCI group, patients with MACE (n?=?14 [18%]) had significantly higher ECP levels than those without (14.4 [9.3–19.5] vs. 4.9 [2.8–10.9] mg/l, P?0.001), and ECP was a significant predictor of MACE (hazard ratio: 1.05, 95% confidence interval [1.01–1.09], P?=?0.021). Within the deferred group, patients with MACE (n?=?8 [9%]) had significantly higher CRP levels than those without (15 [6.5–31.9] vs. 1.6 [0.9–2.9] mg/l, P? |
| Databáze: | OpenAIRE |
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