Effectiveness of Platelet-Rich Plasma Injections for Nonsurgical Management of Carpal Tunnel Syndrome: A Systematic Review and Meta-analysis of Randomized Controlled Trials
| Autor: | Joseph Catapano, Gregory H. Borschel, Lawrence R. Robinson, Michael Catapano, Seyed Mohammad Alavinia, Nimish Mittal |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
030506 rehabilitation
medicine.medical_specialty Visual Analog Scale Visual analogue scale Physical Therapy Sports Therapy and Rehabilitation Subgroup analysis Injections Intra-Articular law.invention 03 medical and health sciences 0302 clinical medicine Randomized controlled trial law Internal medicine medicine Humans Carpal tunnel Carpal tunnel syndrome Randomized Controlled Trials as Topic Platelet-Rich Plasma business.industry Minimal clinically important difference Rehabilitation medicine.disease Carpal Tunnel Syndrome medicine.anatomical_structure Strictly standardized mean difference Meta-analysis 0305 other medical science business 030217 neurology & neurosurgery |
| Zdroj: | Archives of Physical Medicine and Rehabilitation. 101:897-906 |
| ISSN: | 0003-9993 |
| DOI: | 10.1016/j.apmr.2019.10.193 |
| Popis: | Objective To systematically review and evaluate the efficacy and complication profile of platelet-rich plasma (PRP) injection into the carpal tunnel for management of carpal tunnel syndrome (CTS). Data Sources PubMed, MEDLINE, SCOPUS, EMBASE, Google Scholar, Cochrane Central Register of Controlled Trials, and Web of Sciences (from inception to January 1, 2019). Study Selection Controlled trials addressing PRP for CTS. Data Extraction Two reviewers independently screened the titles, abstracts, and full texts, extracting data from eligible studies. The outcomes of interest were the visual analog score (VAS) for pain and the Boston Carpal Tunnel Questionnaire (BCTQ), including the subscales of the symptom severity scale (SSS) and the Functional Status Scale (FSS). Other reported outcome measures and complications were analyzed descriptively. Data Synthesis Four randomized controlled studies satisfied the inclusion criteria and analyzed a total of 191 cases with a final follow-up of either 3 or 6 months. Control groups included splinting in 2 studies, corticosteroid injection in 1 study, and saline injection in 1 study. There was a statistically and clinically significant improvement in the BCTQ (standardized mean difference=-2.06; 95% confidence interval [CI], -3.41 to -0.70; P=.003) between groups. Subgroup analysis showed significant improvement in SSS (standardized mean difference=-1.95; 95% CI, -3.65 to -0.25; P=.02) but not for FSS (standardized mean difference=-2.19; 95% CI, -4.77 to 0.40; P=.10). There was a similar improvement in VAS and nerve conduction studies in those receiving PRP compared to controls. Complication rate in the included studies was low with 4 of 97 participants receiving PRP injections experiencing transient pruritis, burning, or tingling. Conclusions PRP represents a promising therapy for patients with mild to moderate CTS; however, included studies were limited as follow-up was short, the studies included patients that were heterogeneous, and the number of included studies was low. Further investigation is necessary to determine the true efficacy and effect of PRP and to better delineate the long-term results in patients with CTS. |
| Databáze: | OpenAIRE |
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