Trends in kidney failure and kidney replacement therapy in people with diabetes in Hong Kong, 2002-2015: A retrospective cohort study
| Autor: | Ronald C.W. Ma, Alice P.S. Kong, Juliana C.N. Chan, Elaine Chow, Wing-Yee So, Hongjiang Wu, Aimin Yang, Andrea O.Y. Luk, Cheuk-Chun Szeto, Eric S.H. Lau |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
kidney replacement therapy medicine.medical_treatment AAPC Average annual percent change PD Peritoneal dialysis Peritoneal dialysis Internal medicine Diabetes mellitus Internal Medicine medicine RAAS Renin-angiotensin-aldosterone system APC Annual percent change HA Hospital Authority KRT Kidney replacement therapy diabetes RAMP-DM Risk Assessment and Management Programme-Diabetes Mellitus business.industry Health Policy Medical record Incidence (epidemiology) Mortality rate Public Health Environmental and Occupational Health Obstetrics and Gynecology HKDSD Hong Kong Diabetes Surveillance Database Retrospective cohort study medicine.disease mortality Annual Percent Change kidney failure Psychiatry and Mental health EMR Electronic medical record Infectious Diseases trend Pediatrics Perinatology and Child Health incidence HD Hemodialysis Hemodialysis Geriatrics and Gerontology Public aspects of medicine RA1-1270 business Research Paper |
| Zdroj: | The Lancet Regional Health: Western Pacific The Lancet Regional Health. Western Pacific, Vol 11, Iss, Pp 100165-(2021) |
| ISSN: | 2666-6065 |
| Popis: | Background There are limited population-wide trend data on kidney failure and kidney replacement therapy (KRT) in people with diabetes. We conducted a retrospective cohort study to report incidence trends of kidney failure and KRT and related mortality in people with diabetes in Hong Kong between 2002 and 2015. Methods We used territory-wide electronic medical records including laboratory, diagnostic and procedural data to identify people with kidney failure and KRT. We used Joinpoint regression models to estimate the average annual percent change (AAPC) of kidney failure and KRT incidence for entire study period, and annual percent change (APC) for each linear trend segment, along with 1-year and 5-year mortality rates. Findings During 4.9 million person-years of follow-up of 712,222 people with diabetes, 31,425 developed kidney failure, among whom 23.0% (n=7,233) received KRT. The incidence of kidney failure declined by 46.8% from 2002 to 2007 (APC: -11.6, 95% CI: -16.3, -6.7), then flattened from 2007 to 2015 (APC: -0.9, 95% CI: -3.1, 1.3). The incidence of KRT remained constant (AAPC: -1.6, 95% CI: -4.4, 1.2). The 1-year mortality rates declined statistically significantly after both kidney failure and KRT. The 5-year mortality rates declined after kidney failure but the decline was not statistically significant after KRT. Interpretation The findings of our study highlight the importance of developing new strategies to prevent a looming epidemic of kidney failure in people with diabetes in Hong Kong. Funding Asia Diabetes Foundation |
| Databáze: | OpenAIRE |
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