Laser-assisted selection of immotile spermatozoa has no effect on obstetric and neonatal outcomes of TESA-ICSI pregnancies

Autor: Zhulian Wu, Xianyou Gan, Jinhui Shu, Caizhu Wang, Xihe Deng, Kongrong Xu, Ruoyun Lin, Guiting Huang, Chen Huanhua, Hong Zhou
Rok vydání: 2021
Předmět:
Male
Sperm Retrieval
QH471-489
Pregnancy Rate
medicine.medical_treatment
Cell Separation
Intracytoplasmic sperm injection
Miscarriage
Endocrinology
Pregnancy
reproductive and urinary physiology
Azoospermia
Testicular sperm aspiration
Obstetrics
Reproduction
Pregnancy Outcome
Obstetrics and Gynecology
Gestational age
Premature birth
Sperm Motility
Female
Live birth
Adult
endocrine system
China
medicine.medical_specialty
Birth weight
Reproductive medicine
Laser
Fertilization in Vitro
medicine
Humans
Sperm Injections
Intracytoplasmic
Retrospective Studies
Intracytoplasmic spermatozoa injection
Obstetric outcome
urogenital system
business.industry
Research
Lasers
Infant
Newborn
Gynecology and obstetrics
medicine.disease
Reproductive Medicine
Case-Control Studies
RG1-991
Immotile spermatozoa
business
Developmental Biology
Zdroj: Reproductive Biology and Endocrinology : RB&E
Reproductive Biology and Endocrinology, Vol 19, Iss 1, Pp 1-9 (2021)
ISSN: 1477-7827
Popis: Background Azoospermic patients have benefited from both epididymal and testicular spermatozoa intracytoplasmic sperm injection (ICSI) treatment and lasers have been used to identify viable, immotile spermatozoa before the procedure. There are limited studies on the safety of laser-assisted selection of immotile spermatozoa. The aim of this study was to investigate the impact of laser-assisted selection of immotile spermatozoa on the obstetric and neonatal outcomes after ICSI. Methods A retrospective comparative study was conducted on outcomes of ICSI cycles with testicular spermatozoa from June 2014 to June 2018. Of 132 cycles, 33 were allocated to the test group and oocytes were injected with immotile spermatozoa selected by laser, 99 cycles were allocated as control group. Results Compared with the control group, no significant differences were found in the pregnancy, implantation, miscarriage and live birth rates in the test group in either fresh or frozen transfer cycles. The cumulative live birth rate in the test group was 69.70%, which was slightly higher than in the control group (60.61%), but this was not statistically different. There were no differences in the average gestational age, premature birth rate, neonatal birth weight, and the malformation rate between the test and control groups (P > 0.05). In addition, the obstetric outcome between the two groups were not different (P > 0.05). Conclusions No negative effect on perinatal and neonatal outcomes was seen by using laser-assisted selection of immotile spermatozoa for TESA-ICSI. This study endorses the use of laser-assisted selection of viable spermatozoa for ICSI cycles.
Databáze: OpenAIRE
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