Neuroleptic-induced 'painful legs and moving toes' syndrome: successful treatment with clonazepam and baclofen
| Autor: | R. Sandyk |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Baclofen
Causalgia Dyskinesia Drug-Induced Serotonin medicine.medical_specialty Neurology Nerve root Dermatology Clonazepam chemistry.chemical_compound Humans Medicine Molindone gamma-Aminobutyric Acid Leg business.industry General Neuroscience Syndrome General Medicine Middle Aged Toes Surgery body regions Psychiatry and Mental health Dyskinesia chemistry Anesthesia Schizophrenia Female Neurology (clinical) Neurosurgery medicine.symptom business Molindone Hydrochloride medicine.drug |
| Zdroj: | The Italian Journal of Neurological Sciences. 11:573-576 |
| ISSN: | 1590-3478 0392-0461 |
| DOI: | 10.1007/bf02337440 |
| Popis: | The syndrome of "painful legs and moving toes" is characterised by spontaneous causalgic pain in the lower extremities associated with peculiar involuntary movements of the toes and feet. It has been observed after a variety of lesions affecting the posterior nerve roots, the spinal ganglia and the peripheral nerves. The pathophysiology of the syndrome is unknown. I report a patient who developed the syndrome during treatment for schizophrenia with the antipsychotic agent molindone hydrochloride. The patient's response to the combination of clonazepam and baclofen suggests that the pathophysiology of the "painful legs and moving toes" may be linked to impairment of spinal serotonergic and GABA functions. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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