Crystal structure of pirfenidone (5-methyl-1-phenyl-1H-pyridin-2-one): an active pharmaceutical ingredient (API)
| Autor: | Valentina Colombo, Matteo Mossotti, Mauro Barbero, Angelo Sironi, Giovanni B. Giovenzana |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
crystal structure
Crystal structure 010402 general chemistry 01 natural sciences Crystal chemistry.chemical_compound medicine active pharmaceutical ingredient (API) General Materials Science Active ingredient Crystallography 010405 organic chemistry Chemistry Hydrogen bond General Chemistry Pirfenidone Condensed Matter Physics hydrogen bonding Acceptor Toluene 0104 chemical sciences QD901-999 pirfenidone idiopathic pulmonary fibrosis (IPF) medicine.drug Monoclinic crystal system |
| Zdroj: | Acta Crystallographica Section E: Crystallographic Communications, Vol 75, Iss 7, Pp 984-986 (2019) |
| ISSN: | 2056-9890 |
| Popis: | The crystal structure of pirfenidone, C12H11NO [alternative name: 5-methyl-1-phenylpyridin-2(1H)-one], an active pharmaceutical ingredient (API) approved in Europe and Japan for the treatment of Idiopathic pulmonary fibrosis (IPF), is reported here for the first time. It was crystallized from toluene by the temperature gradient technique, and crystallizes in the chiral monoclinic space groupP21. The phenyl and pyridone rings are inclined to each other by 50.30 (11)°. In the crystal, molecules are linked by C–H...O hydrogen bonds involving the same acceptor atom, forming undulating layers lying parallel to theabplane. |
| Databáze: | OpenAIRE |
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