Presynaptic boutons that contain mitochondria are more stable
| Autor: | Robert M. Lees, James D. Johnson, Michael C. Ashby |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
En passant presynaptic bouton Mitochondrion lcsh:RC321-571 Presynaptic bouton Cellular and Molecular Neuroscience 03 medical and health sciences 0302 clinical medicine neocortex medicine in vivo 2-photon imaging lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry synapse turnover 030304 developmental biology 0303 health sciences synaptic plasticity Neocortex Chemistry fungi Cell Biology Brief Research Report Cell biology mitochondria 030104 developmental biology medicine.anatomical_structure Neuronal circuits nervous system Synaptic plasticity Structural plasticity Biophysics Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Frontiers in Synaptic Neuroscience Frontiers in Synaptic Neuroscience, Vol 11 (2020) Lees, R M, Johnson, J D & Ashby, M C 2020, ' Presynaptic boutons that contain mitochondria are more stable ', Frontiers in Synaptic Neuroscience, vol. 11, 37 . https://doi.org/10.3389/fnsyn.2019.00037 |
| DOI: | 10.1101/580530 |
| Popis: | Addition and removal of presynaptic terminals reconfigures neuronal circuits of the mammalian neocortex, but little is known about how this presynaptic structural plasticity is controlled. Since mitochondria can regulate presynaptic function, we investigated whether the presence of axonal mitochondria relates to structural plasticity of presynaptic boutons in mouse neocortex. We found that the overall density of axonal mitochondria did not appear to influence loss and gain of boutons. However, positioning of mitochondria at individual presynaptic sites did relate to increased stability of those boutons. In line with this, synaptic localisation of mitochondria increased as boutons aged and showed differing patterns of localisation aten passantandterminauxboutons. These results suggest that mitochondria accumulate locally at boutons over time to increase bouton stability. |
| Databáze: | OpenAIRE |
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