The influence of drug treatment on cardio-vascular system of the rats with congenital hypothyroidism
| Autor: | Rostyslav F. Kaminsky, Olena Holubchenko, Svetlana M. Chuhray, Iryna V. Dzevulska, Viktoria E. Lavrynenko, Ruzhena M. Matkivska, L. M. Sokurenko, Olena Ustymenko, Oleksandr Kovalchuk |
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| Předmět: |
medicine.medical_specialty
business.industry Thyroid General Medicine 030204 cardiovascular system & hematology medicine.disease Congenital hypothyroidism 03 medical and health sciences 0302 clinical medicine Pharmacotherapy medicine.anatomical_structure Endocrinology Blood pressure Calcitonin Internal medicine Circulatory system Blood plasma medicine Plethysmograph 030212 general & internal medicine business hormones hormone substitutes and hormone antagonists |
| Zdroj: | Scopus-Elsevier |
| Popis: | Objective Introduction: In the treatment of hypothyroidism substitution therapy with L-thyroxine is used, it is also advisable to use the metabolites with membrane-stabilizing properties that normalize the metabolism in the body, for example, calcitonin, which significantly reduces the depth of the dystrophic phenomena in the myocardium. The aim was to study the patterns of structural changes in the left ventricular myocardial capillaries of rats with congenital hypothyroidism in combinative drug therapy with L-thyroxine and calcitonin. Patients and methods Materials and methods: 30 white Wistar line rats were used as experimental animals: 10 with treatment and 10 without as well as control - 10 intact Wistar line rats of the same age. Mercazolil was used to inhibit thyroid gland in order to model congenital hypothyroidism. After birth, the rats received L-thyroxine at a dose of 10 μg / kg per os daily, calcitonin at a dose of 1.0 MU / kg per day intramuscularly, then with mother's milk, later by themselves for 100 days. The arterial pressure was measured in all experimental groups during extraction from the experiment by plethysmograph, their left ventricular myocardium was examined under electron microscope and micropinocytotic vesicles in their cells were studied morphometrically. Results Results: In rats with congenital hypothyroidism, for which L-thyroxin drug in combination with calcitonin was used as a substitution therapy, after pharmacological correction, in general there is no pronounced heteromorphism of the ultrastructure of the left ventricular myocardial blood capillaries, which was characteristic for animals without pharmacological correction. The analysis showed normalization of the content of free thyroxine in blood plasma and blood pressure of rats with congenital hypothyroidism after complex substitution therapy. Conclusion Conclusions: In rats with congenital hypothyroidism, which received L-thyroxine and calcitonin at birth, the myocardium capillaries generally remain intact and have morphological and functional characteristics similar to intact animals, which is the theoretical basis for the need for calcitonin to be used in substitution therapy in hypothyroidism. |
| Databáze: | OpenAIRE |
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