Enantioselective alpha-Arylation of Benzamides via Synergistic Nickel and Metallaphotoredox Catalysis

Autor:	Alexander W. Rand, John Montgomery
Rok vydání:	2019
Předmět:	chemistry.chemical_compound Nickel chemistry Aryl Functional group Enantioselective synthesis chemistry.chemical_element Iridium Enantiomeric excess Combinatorial chemistry Catalysis Stereocenter
DOI:	10.26434/chemrxiv.9978824.v1
Popis:	A new method to access alpha-arylated benzamides has been enabled by metallaphotoredox catalysis. This system allows for non-directed C–H functionalization of N-alkyl benzamides using a dual nickel/iridium catalytic system to form tertiary stereocenters in good enantiomeric excess and moderate yields. This reaction shows excellent functional group compatibility and can be performed using a number of sterically and electronically different aryl bromides and secondary benzamides.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::099807aa83fd37910ce247f2cb003c72 https://doi.org/10.26434/chemrxiv.9978824.v1 Zobrazit plný text záznamu