Fine mapping and positional candidate studies identify HLA-G as an asthma susceptibility gene on chromosome 6p21
| Autor: | Julian Solway, Eugene R. Bleecker, Nina Patel, Dan L. Nicolae, Timothy D. Howard, Rodney Parry, Carole Ober, Steven R. White, Daniel Schneider, Paul Kogut, Nancy J. Cox, Christine Billstrand, Jeffrey M. Goodenbour, Raoul L. Wolf, Gerard H. Koppelman, Susan Kuldanek, Joan S. Hunt, Joseph Donfack, Deborah A. Meyers, Lucille A. Lester, Dirkje S. Postma, Zheng Tan |
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| Přispěvatelé: | Faculteit Medische Wetenschappen/UMCG, Groningen Research Institute for Asthma and COPD (GRIAC) |
| Rok vydání: | 2004 |
| Předmět: |
EXPRESSION
Adult Male Linkage disequilibrium LINKAGE DISEQUILIBRIUM Human leukocyte antigen Biology MATERNAL-FETAL INTERFACE Genetic determinism REGION FOUNDER POPULATION 03 medical and health sciences 0302 clinical medicine Gene mapping HLA Antigens HLA-G Report medicine Genetics Humans Genetics(clinical) Genetic Predisposition to Disease Genetic Testing Child Gene Genetics (clinical) 030304 developmental biology Genetic testing HLA-G Antigens 0303 health sciences IDENTIFICATION medicine.diagnostic_test TRANSPLANTATION Histocompatibility Antigens Class I Chromosome Mapping Asthma 3. Good health Transplantation Phenotype GENOME-WIDE SEARCH CELLS Immunology Chromosomes Human Pair 6 Female Bronchial Hyperreactivity INFLAMMATORY-BOWEL-DISEASE 030215 immunology |
| Zdroj: | American Journal of Human Genetics, 76(2), 349-357. CELL PRESS University of Groningen |
| ISSN: | 0002-9297 |
| Popis: | Asthma affects nearly 14 million people worldwide and has been steadily increasing in frequency for the past 50 years. Although environmental factors clearly influence the onset, progression, and severity of this disease, family and twin studies indicate that genetic variation also influences susceptibility. Linkage of asthma and related phenotypes to chromosome 6p21 has been reported in seven genome screens, making it the most replicated region of the genome. However, because many genes with individually small effects are likely to contribute to risk, identification of asthma susceptibility loci has been challenging. In this study, we present evidence from four independent samples in support of HLA-G as a novel asthma and bronchial hyperresponsiveness susceptibility gene in the human leukocyte antigen region on chromosome 6p21, and we speculate that this gene might contribute to risk for other inflammatory diseases that show linkage to this region. |
| Databáze: | OpenAIRE |
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