Exploiting the Proton Exchange as an Additional Route to Enhance the Relaxivity of Paramagnetic MRI Contrast Agents
| Autor: | Zsolt Baranyai, Daniela Delli Castelli, Luciano Lattuada, Silvio Aime, Simona Baroni, Roberta Napolitano, Fabio Tedoldi, Alberto Fringuello Mingo, István Fábián, Ernő Brücher, Sonia Colombo Serra |
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| Rok vydání: | 2018 |
| Předmět: |
Proton
Contrast Media Gadolinium 010402 general chemistry 01 natural sciences Inorganic Chemistry Heterocyclic Compounds 1-Ring Paramagnetism chemistry.chemical_compound Heterocyclic Compounds Organometallic Compounds Molecule Moiety Physical and Theoretical Chemistry Hydrogen-Ion Concentration Molecular Structure Magnetic Resonance Imaging Protons 1-Ring Hydroxyl proton 010405 organic chemistry Ligand Relaxation (NMR) 0104 chemical sciences Crystallography chemistry Derivative (chemistry) |
| Zdroj: | Inorganic Chemistry. 57:5567-5574 |
| ISSN: | 1520-510X 0020-1669 |
| DOI: | 10.1021/acs.inorgchem.8b00521 |
| Popis: | The relaxivity of Gd(HP-DO3A) was studied as a function of pH and buffer composition in order to identify the main factors of the observed relaxation enhancement due to the exchange of the coordinated hydroxyl proton. It was established that the paramagnetic relaxation time, T1M, of the coordinated hydroxyl proton is about 50% shorter than that of the protons in the coordinated water molecule. The control of the p K of the coordinated alcoholic -OH moiety in the ligand is fundamental to utilize the proton exchange enhanced relaxivity under physio/pathologic conditions. A new derivative of Gd(HP-DO3A) was synthesized by replacing the -CH3 group with a -CF3 moiety. In this complex, the -OH group becomes more acidic. Consequently, the maximum contribution of the proton exchange to the relaxivity is shifted to a lower pH region with the fluorinated ligand. |
| Databáze: | OpenAIRE |
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