The red cell distribution width as a prognostic indicator in upper aerodigestive tract (UADT) cancer: A systematic review and meta-analysis
| Autor: | Sushma Teegala, Peter Costantino, Tristan Tham, Wendy Saori Herman, Yonatan Bardash |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Oncology Erythrocyte Indices medicine.medical_specialty business.industry Hazard ratio Cancer Red blood cell distribution width Cochrane Library medicine.disease Prognosis 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Upper aerodigestive tract Otorhinolaryngology Head and Neck Neoplasms 030220 oncology & carcinogenesis Internal medicine Meta-analysis Carcinoma Medicine Humans business |
| Zdroj: | American journal of otolaryngology. 39(4) |
| ISSN: | 1532-818X |
| Popis: | Purpose The aim of this systematic review and meta-analysis was to investigate the relationship between the Red Cell Distribution Width (RDW) and prognosis in upper aerodigestive tract (UADT) cancer. Methods PubMed (via the web), Embase, Scopus, and the Cochrane Library were searched. A systematic review and meta-analysis was done to generate the pooled hazard ratios (HR) for overall survival (OS), disease specific survival (DSS), and recurrence free survival (RFS). Results Our analysis included the results of 4200 patients in 8 cohorts. The pooled data demonstrated that an elevated RDW was associated with significantly poorer OS (HR: 1.44, 95% CI: 1.13–1.83), RFS (HR: 1.43, 95%CI: 1.13–1.82). The DSS result had high heterogeneity and 95% CI was not pooled. Conclusions An elevated RDW may be an indicator of poor prognosis in UADT cancers in certain populations. Further research is needed to confirm this effect. |
| Databáze: | OpenAIRE |
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