Genome-wide association and HLA region fine-mapping studies identify susceptibility loci for multiple common infections
Autor: | Chao Tian, Suzanne M. Noble, Bethann S. Hromatka, Nicholas Eriksson, David A. Hinds, Joyce Y. Tung, Amy K. Kiefer |
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Jazyk: | angličtina |
Rok vydání: | 2017 |
Předmět: |
0301 basic medicine
Male Mononucleosis General Physics and Astronomy Common Cold Chickenpox HLA Antigens lcsh:Science Multidisciplinary Hepatitis A Pharyngitis Hepatitis B 3. Good health Tonsillitis Urinary Tract Infections Rheumatic fever Female Rheumatic Fever Warts Scarlet Fever Strep throat Science Ear infection Infections Rubella Herpes Zoster General Biochemistry Genetics and Molecular Biology White People Article Meningitis Bacterial 03 medical and health sciences Streptococcal Infections medicine Humans Tuberculosis Genetic Predisposition to Disease Infectious Mononucleosis Sinusitis Mumps Candidiasis Vulvovaginal Tonsillectomy business.industry Tuberculin Test General Chemistry Pneumonia medicine.disease Middle Ear Ventilation Otitis Media 030104 developmental biology Case-Control Studies Immunology Chronic Disease Scarlet fever lcsh:Q Herpes Labialis business Genome-Wide Association Study Measles |
Zdroj: | Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017) Nature Communications |
ISSN: | 2041-1723 |
Popis: | Infectious diseases have a profound impact on our health and many studies suggest that host genetics play a major role in the pathogenesis of most of them. We perform 23 genome-wide association studies for common infections and infection-associated procedures, including chickenpox, shingles, cold sores, mononucleosis, mumps, hepatitis B, plantar warts, positive tuberculosis test results, strep throat, scarlet fever, pneumonia, bacterial meningitis, yeast infections, urinary tract infections, tonsillectomy, childhood ear infections, myringotomy, measles, hepatitis A, rheumatic fever, common colds, rubella and chronic sinus infection, in over 200,000 individuals of European ancestry. We detect 59 genome-wide significant (P Susceptibility to infectious diseases is, among others, influenced by the genetic landscape of the host. Here, Tian and colleagues perform genome-wide association studies for 23 common infections and find 59 risk loci for 17 of these, both within the HLA region and non-HLA loci. |
Databáze: | OpenAIRE |
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