Genome-wide association and HLA region fine-mapping studies identify susceptibility loci for multiple common infections

Autor: Chao Tian, Suzanne M. Noble, Bethann S. Hromatka, Nicholas Eriksson, David A. Hinds, Joyce Y. Tung, Amy K. Kiefer
Jazyk: angličtina
Rok vydání: 2017
Předmět:
0301 basic medicine
Male
Mononucleosis
General Physics and Astronomy
Common Cold
Chickenpox
HLA Antigens
lcsh:Science
Multidisciplinary
Hepatitis A
Pharyngitis
Hepatitis B
3. Good health
Tonsillitis
Urinary Tract Infections
Rheumatic fever
Female
Rheumatic Fever
Warts
Scarlet Fever
Strep throat
Science
Ear infection
Infections
Rubella
Herpes Zoster
General Biochemistry
Genetics and Molecular Biology
White People
Article
Meningitis
Bacterial
03 medical and health sciences
Streptococcal Infections
medicine
Humans
Tuberculosis
Genetic Predisposition to Disease
Infectious Mononucleosis
Sinusitis
Mumps
Candidiasis
Vulvovaginal
Tonsillectomy
business.industry
Tuberculin Test
General Chemistry
Pneumonia
medicine.disease
Middle Ear Ventilation
Otitis Media
030104 developmental biology
Case-Control Studies
Immunology
Chronic Disease
Scarlet fever
lcsh:Q
Herpes Labialis
business
Genome-Wide Association Study
Measles
Zdroj: Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Nature Communications
ISSN: 2041-1723
Popis: Infectious diseases have a profound impact on our health and many studies suggest that host genetics play a major role in the pathogenesis of most of them. We perform 23 genome-wide association studies for common infections and infection-associated procedures, including chickenpox, shingles, cold sores, mononucleosis, mumps, hepatitis B, plantar warts, positive tuberculosis test results, strep throat, scarlet fever, pneumonia, bacterial meningitis, yeast infections, urinary tract infections, tonsillectomy, childhood ear infections, myringotomy, measles, hepatitis A, rheumatic fever, common colds, rubella and chronic sinus infection, in over 200,000 individuals of European ancestry. We detect 59 genome-wide significant (P
Susceptibility to infectious diseases is, among others, influenced by the genetic landscape of the host. Here, Tian and colleagues perform genome-wide association studies for 23 common infections and find 59 risk loci for 17 of these, both within the HLA region and non-HLA loci.
Databáze: OpenAIRE
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