Anti-inflammatory canthin-6-one alkaloids from the roots of Thailand Eurycoma longifolia Jack
| Autor: | Zhao Wei, Ying Zhang, Tao Wang, Jingya Ruan, Zheng Li, Lifeng Han, Yi Zhang, Nuttapong Wichai |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Traditional medicine
biology Plant Extracts 010405 organic chemistry Chemistry medicine.drug_class Pharmacology toxicology Thailand biology.organism_classification Plant Roots 01 natural sciences Anti-inflammatory Indole Alkaloids 0104 chemical sciences 010404 medicinal & biomolecular chemistry Canthin-6-one medicine Raw264 7 cell Molecular Medicine Eurycoma longifolia Eurycoma No production Carbolines No release |
| Zdroj: | Journal of Natural Medicines. 74:804-810 |
| ISSN: | 1861-0293 1340-3443 |
| Popis: | Two new canthin-6-one alkaloids, 4,9-dimethoxy-5-hydroxycanthin-6-one (1) and 9-methoxy-(R/S)-5-(1-hydroxyethyl)-canthin-6-one (2), together with fifteen known ones were isolated from the roots of Thailand Eurycoma longifolia Jack. Among the known canthin-6-one alkaloids, compounds 9 and 16 were isolated from the Eurycoma genus for the first time. Meanwhile, the nitric oxide (NO) inhibitory activities of all isolates were examined in lipopolysaccharide (LPS)-stimulated RAW264.7 cells at 50 µM. Moreover, a dose-dependent experiment was conducted for active compounds 1, 2, 4, 6, 7, 10, 12–17 at the concentration of 10, 25, and 50 µM, respectively. Consequently, compounds 1, 4, 6, 7, 12, 14, 15, as well as 17 were found to inhibit NO release from RAW264.7 cells in a dose-dependent manner. Two new canthin-6-one alkaloids, 4,9-dimethoxy-5-hydroxycanthin-6-one (1) and 9-methoxy-(R/S)-5-(1-hydroxyethyl)-canthin-6-one (2), together with fifteen known ones were isolated from the roots of Thailand Eurycoma longifolia Jack. Among them, 1, 4, 6, 7, 12, 14, 15, as well as 17 were found to inhibit NO release from RAW264.7 cells in a dose-dependent manner at the concentration of 10, 25, and 50 µM. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink