Induction of HTLV-III/LAV from a Nonvirus-Producing T-Cell Line: Implications for Latency
| Autor: | Malcolm A. Martin, D. Powell, Thomas M. Folks, Steven Benn, M. Lightfoote, Anthony S. Fauci |
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| Rok vydání: | 1986 |
| Předmět: |
Time Factors
T-Lymphocytes viruses T cell Biology Deltaretrovirus Virus Cell Line chemistry.chemical_compound Idoxuridine Gene expression medicine Humans Latency (engineering) Acquired Immunodeficiency Syndrome Multidisciplinary Models Genetic food and beverages T lymphocyte Provirus Virology Deoxyuridine medicine.anatomical_structure chemistry Cell culture Immunology Virus Activation |
| Zdroj: | Science. 231:600-602 |
| ISSN: | 1095-9203 0036-8075 |
| Popis: | When the human T-cell line A3.01 is infected with HTLV-III/LAV, the virus associated with the acquired immune deficiency syndrome (AIDS), most of the cells are killed. However, a small number of cells that lack the Leu-3 surface marker survive. Under normal conditions these surviving cells do not produce virus, nor can they be infected by the virus, but they can be induced to produce virus by treatment with 5-iodo-2'-deoxyuridine. This response can be induced for as long as 3 months after the initial infection, suggesting that the cells may harbor a latent form of HTLV-III/LAV. |
| Databáze: | OpenAIRE |
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