Effect of Esmolol Given During Cardiopulmonary Bypass on Fractional Area of Contraction from Transesophageal Echocardiography
| Autor: | Daniel M. Azari, Stephen Aufderheide, Kathryn A. K. McQueen, Randall C. Cork, Mohammed Naraghi, Mark R. Mitchell |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Cardiac function curve
medicine.medical_specialty Adrenergic beta-Antagonists Hemodynamics Blood Pressure Placebo Ventricular Function Left law.invention Placebos Propanolamines Oxygen Consumption Bolus (medicine) Double-Blind Method Heart Rate Hypothermia Induced law Internal medicine medicine Cardiopulmonary bypass Humans Prospective Studies Cardiac Output Infusions Intravenous Cardiopulmonary Bypass Ejection fraction business.industry Stroke Volume Stroke volume Middle Aged Esmolol Myocardial Contraction Oxygen surgical procedures operative Anesthesiology and Pain Medicine Anesthesia Cardiology business Echocardiography Transesophageal circulatory and respiratory physiology medicine.drug |
| Zdroj: | Anesthesia & Analgesia. 81:219-224 |
| ISSN: | 0003-2999 |
| Popis: | The infusion of esmolol during hypothermic cardiopulmonary bypass (CPB) has no negative myocardial effects after CPB, despite increased esmolol levels during CPB due to hypothermia.The purpose of this randomized, double-blind, prospective study was to measure the effects of esmolol infused during CPB on cardiac function as measured by calculated indices of cardiac work and by transesophageal echocardiography (TEE). Patients scheduled for CPB were randomized to receive intravenous esmolol (300 micro gram centered dot kg-1 centered dot min-1 during CPB after bolus of 2 mg/kg prior to CPB) or placebo. Infusion was stopped at 10 min after release of aortic cross-clamp. Hemodynamics and TEE were recorded during the procedure. Fractional area of contraction (FAC), an approximation of left ventricular ejection fraction, was calculated from end-diastolic and end-systolic areas. Esmolol was administered to 15 patients and placebo to 14. Heart rates in the esmolol group were lower during infusion and prior to CPB (P < 0.05). Stroke volume index and left ventricular stroke work index were higher in the esmolol group at 15 min post-CPB (P < 0.05). FAC was higher in the esmolol group at 15 and 30 min post-CPB (P < 0.05), but no difference was observed between groups at 1 h post-CPB. Esmolol infused during CPB in this series of patients was associated with better left ventricular function during the first 0.5 h post-CPB. (Anesth Analg 1995;81:219-24) |
| Databáze: | OpenAIRE |
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