Hyperuricemia in predialysis chronic kidney disease patients in Southern Nigeria
Autor: | Enajite I Okaka, Oluseyi Ademola Adejumo, Chimezie Godswill Okwuonu, Ojogwu Li |
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Jazyk: | angličtina |
Rok vydání: | 2016 |
Předmět: |
medicine.medical_specialty
030232 urology & nephrology Blood lipids Nigeria lcsh:Medicine hyperuricemia 030204 cardiovascular system & hematology urologic and male genital diseases 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine Hypertensive Nephropathy Chronic kidney disease Medicine Hyperuricemia Creatinine predialysis business.industry lcsh:R nutritional and metabolic diseases General Medicine medicine.disease chemistry Physical therapy business Body mass index Dyslipidemia Kidney disease Blood sampling |
Zdroj: | Sahel Medical Journal, Vol 19, Iss 1, Pp 21-26 (2016) |
ISSN: | 2321-6689 |
Popis: | Background: Cardiovascular disease (CVD) is the leading cause of hospitalization and death in chronic kidney disease (CKD) patients. Hyperuricemia has emerged as one of the nontraditional cardiovascular risk factors. Studies have shown that hyperuricemia plays a major role in the development of CVD and rapid progression of CKD to end-stage renal disease. Objective: The aim was to determine the prevalence and pattern of hyperuricemia in predialysis CKD patients attending a teaching hospital in Southern Nigeria. Methodology: One hundred and twenty consecutive predialysis CKD patients and 40 control subjects with normal renal function were recruited over 2 years. Data obtained from participants included demographics, body mass index, blood pressure reading, and etiology of CKD. Blood sampling was done for the determination of serum uric acid, creatinine, and fasting serum lipids. P < 0.05 were taken as significant. Results: The mean age of the CKD subjects was 48.8 ± 16.6 years with a male:female ratio of 1.7:1. The prevalence of hyperuricemia in the CKD subjects was 47.5% and this was significantly higher than 15% observed in the control group (P ≤ 0.001). The prevalence of hyperuricemia was highest in CKD stage 3b. Hyperuricemia was more prevalent in younger predialysis CKD subjects and those with hypertensive nephropathy. There was no significant association between hyperuricemia, obesity, gender and dyslipidemia in this study. Conclusion: Hyperuricemia is highly prevalent in young predialysis CKD patients even in the early stages. Measures to reduce hyperuricemia should be put in place especially lifestyle and dietary modification. |
Databáze: | OpenAIRE |
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