STUDIES OF SPACEFLIGHT EFFECTS ON A 3D MODEL OF CHONDROBLAST CULTURE
| Autor: | I E Nefedova, V. V. Rossinskaya, E. I. Pugachev, Larisa T. Volova, M. N. Milyakova, V V Boltovskaya, L. N. Kulagina |
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| Rok vydání: | 2016 |
| Předmět: |
Materials science
Spacecraft Weightlessness Chondroblast business.industry Hyaline cartilage Cell Culture Techniques 3d model General Medicine Space Flight Spaceflight General Biochemistry Genetics and Molecular Biology law.invention Chondrocytes medicine.anatomical_structure Cell culture law Cell Adhesion medicine Humans business Biomedical engineering |
| Zdroj: | Europe PubMed Central |
| ISSN: | 0233-528X |
| DOI: | 10.21687/0233-528x-2016-50-5-11-17 |
| Popis: | The effect of long-duration space flight on the vital processes in human chondroblasts in vitro was studied with a number of morphologic, biochemical and optic techniques. Object of investigation was a 3-D porous biocarrier populated by a cell culture in a leak-free vessel completely full of growth medium. The investigation was performed onboard automatic .spacecraft Foton-M4 with the use of research equipment SIGMA. Synchronous experiments were conducted in ground laboratory. The experiment with cell culture prepared of the human hyaline cartilage validated suitability of this model for long-duration experiments with adhesive cells on automatic spacecraft; besides, the experimental results suggest that in spaceflight microgravity adhesive cells exist in the state of suspension. |
| Databáze: | OpenAIRE |
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