Spontaneous remission of ectopic Cushing's syndrome due to pheochromocytoma: a case report
| Autor: | Allan H Shlossberg, Rekha Gupta, Keh-Chuan Loh |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Adult
endocrine system medicine.medical_specialty Pathology endocrine system diseases Endocrinology Diabetes and Metabolism Remission Spontaneous Adrenal Gland Neoplasms Spontaneous remission Pheochromocytoma Pathogenesis Cushing syndrome Endocrinology Internal medicine medicine Humans Cushing Syndrome business.industry General Medicine Hyperplasia medicine.disease ACTH Syndrome Ectopic Female Ketoconazole Tomography X-Ray Computed business Complication hormones hormone substitutes and hormone antagonists Immunostaining medicine.drug |
| Zdroj: | European Journal of Endocrinology. 135:440-443 |
| ISSN: | 1479-683X 0804-4643 |
| DOI: | 10.1530/eje.0.1350440 |
| Popis: | Loh K-C, Gupta R, Shlossberg AH. Spontaneous remission of ectopic Cushing's syndrome due to pheochromocytoma: a case report. Eur J Endocrinol 1996;135:440–3. ISSN 0804–4643 A young female adult with Cushing's syndrome arising from ectopic production of corticotropin (ACTH) from an adrenal pheochromocytoma showed spontaneous clinical and biochemical remission of hypercortisolism after a brief period of ketoconazole administration. Despite continued remission of the hypercortisolism over the next 18 months, there was progressive catecholamine hypersecretion with significant morbidity as a result of the pheochromocytoma. Surgical resection of the left adrenal gland revealed a pheochromocytoma showing focal cytoplasmic immunostaining for ACTH and marked diffuse compact cell hyperplasia in the adrenocortical tissue. To our knowledge this is the first reported case of spontaneous clinical and biochemical remission of ectopic ACTH production from a pheochromocytoma. The pathogenesis of the remission remains unknown. Keh-Chuan Loh, Division of Endocrinology and Metabolism, Dalhousie University, 5303 Morris Street, Halifax, Nova Scotia B3J 1B6, Canada |
| Databáze: | OpenAIRE |
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