Prevalence of Human Papillomavirus, Human Immunodeficiency Virus, and Other Sexually Transmitted Infections Among Men Who Have Sex With Men in Togo: A National Cross-sectional Survey

Autor: Fifonsi Adjidossi Gbeasor-Komlanvi, Anoumou Dagnra, Mounerou Salou, Didier K. Ekouevi, Valentine Marie Ferré, Charlotte Charpentier, Quentin Le Hingrat, Antoine Jaquet, Gilles Collin, Diane Descamps
Rok vydání: 2018
Předmět:
0301 basic medicine
Microbiology (medical)
Adult
Male
medicine.medical_specialty
Adolescent
Cross-sectional study
030106 microbiology
Sexually Transmitted Diseases
HIV Infections
medicine.disease_cause
Men who have sex with men
03 medical and health sciences
Young Adult
0302 clinical medicine
Risk Factors
Surveys and Questionnaires
Prevalence
Medicine
Anal cancer
Humans
Public Health Surveillance
030212 general & internal medicine
Homosexuality
Male
Papillomaviridae
biology
business.industry
Obstetrics
Coinfection
Incidence (epidemiology)
Papillomavirus Infections
virus diseases
HIV
Odds ratio
Hepatitis B
medicine.disease
biology.organism_classification
3. Good health
Infectious Diseases
Cross-Sectional Studies
Togo
Female
Disease Susceptibility
business
Chlamydia trachomatis
Mycoplasma genitalium
Zdroj: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 69(6)
ISSN: 1537-6591
Popis: Background Sub-Saharan Africa is a region of both high human immunodeficiency virus (HIV) and anal cancer incidence. We conducted the first national study in Togo to assess human papillomavirus (HPV), HIV, and other sexually transmitted infection (STI) prevalence among men who have sex with men (MSM). Methods A multicentric cross-sectional study was conducted among MSM recruited in 4 Togolese cities. Anal swabs were collected to test HPV, herpes simplex virus (HSV), and 7 STIs. Results Among the 207 MSM, HIV and high-risk HPV (hrHPV) overall prevalence were 26.1% and 44.9%, respectively. The most common hrHPV types were HPV-35 (15.0%) and HPV-16 (13.0%). Prevalence of hrHPV and multiple HPV infections were higher among HIV-infected than among HIV-uninfected MSM (85.2% vs 30.7%, P < 10–5 and 85.2% vs 28.7%, P < 10–5, respectively). Other STIs, except hepatitis B virus, were also more prevalent among HIV-infected MSM (Neisseria gonorrhoeae, P = .03; Mycoplasma genitalium, P = .04; HSV-2, P = .001; and a trend for Chlamydia trachomatis, P = .06). In multivariate analysis (adjusted odds ratio [95% confidence interval]), HIV (10.1 [4.0–25.6]), living in Lomé (2.8 [1.1–7.1]), HSV-2 excretion (26.7 [2.9–244.3]), C. trachomatis (11.7 [2.3–58.9]), and M. genitalium infection (9.6 [3.1–29.9]) were associated with increased risk of hrHPV infection. Conclusions We report a high burden of anal STIs with an unusual hrHPV type distribution among MSM, highlighting the critical need of implementation of a national strategy regarding prevention of STIs and vaccination against HPV.
Databáze: OpenAIRE
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