Genome sequence of the human malaria parasite Plasmodium falciparum
| Autor: | Man Suen Chan, Alan H. Fairlamb, Jeremy D. Selengut, Leda M. Cummings, Arnab Pain, Vishvanath Nene, Martin Fraunholz, G. Mani Subramanian, Christopher J. Mungall, Akhil B. Vaidya, Bart Barrell, Jane M. Carlton, Jeremy Peterson, Chris I. Newbold, Richard W. Hyman, Daniel J. Carucci, Claire M. Fraser, Neil Hall, Matthew Berriman, Michael W. Mather, David S. Roos, Jonathan A. Eisen, Ronald W. Davis, Sue Kyes, Jonathan E. Allen, Eula Fung, Kim Rutherford, Geoffrey I. McFadden, Samuel V. Angiuoli, Karen E. Nelson, Owen White, J. Craig Venter, Alister Craig, Steven L. Salzberg, Shamira J. Shallom, Mihaela Pertea, David M. A. Martin, Stuart A. Ralph, Bernard B. Suh, Daniel H. Haft, Keith D. James, Ian T. Paulsen, Stephen L. Hoffman, Sharen Bowman, Malcolm J. Gardner |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
DNA Replication
Genome evolution DNA Repair Proteome Molecular Sequence Data Plasmodium falciparum Protozoan Proteins Genomics Biology Genome Article Evolution Molecular parasitic diseases Malaria Vaccines Animals Humans Plastids Malaria Falciparum Gene Genetics Recombination Genetic Pregnancy-associated malaria Apicoplast Multidisciplinary Membrane Transport Proteins Sequence Analysis DNA DNA Protozoan biology.organism_classification Chromosome Structures Genome Protozoan |
| Zdroj: | ResearcherID |
| Popis: | The parasite Plasmodium falciparum is responsible for hundreds of millions of cases of malaria, and kills more than one million African children annually. Here we report an analysis of the genome sequence of P. falciparum clone 3D7. The 23-megabase nuclear genome consists of 14 chromosomes, encodes about 5,300 genes, and is the most (A + T)-rich genome sequenced to date. Genes involved in antigenic variation are concentrated in the subtelomeric regions of the chromosomes. Compared to the genomes of free-living eukaryotic microbes, the genome of this intracellular parasite encodes fewer enzymes and transporters, but a large proportion of genes are devoted to immune evasion and host-parasite interactions. Many nuclear-encoded proteins are targeted to the apicoplast, an organelle involved in fatty-acid and isoprenoid metabolism. The genome sequence provides the foundation for future studies of this organism, and is being exploited in the search for new drugs and vaccines to fight malaria. |
| Databáze: | OpenAIRE |
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