Zoledronic acid for treatment of Paget's disease of bone
| Autor: | Jean-Pierre Devogelaer, Daniel Manicourt |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment Disease Zoledronic Acid Bone resorption Lesion medicine Deformity Animals Humans Pharmacology (medical) Bone pain Pharmacology Clinical Trials as Topic Bone Density Conservation Agents Diphosphonates business.industry Imidazoles General Medicine Bisphosphonate Osteitis Deformans medicine.disease Surgery Paget's disease of bone Zoledronic acid medicine.symptom business medicine.drug |
| Zdroj: | Expert Opinion on Pharmacotherapy. 8:2863-2869 |
| ISSN: | 1744-7666 1465-6566 |
| Popis: | Paget's disease of bone is characterised by a focal increase in bone resorption and bone formation. This anarchic metabolism leads to disorganised bone, with bone pain, fragility, deformity and compression of the peripheral or CNS according to the involved site. Quality of life of sufferers is dramatically impaired. Symptomatic therapy trends to relieve pain, but cannot seek to prevent other complications. Only 'specific' therapy can fulfil this purpose. Bisphosphonates have become the cornerstone for therapy of Paget's disease in the last 25 years. Progressively stronger bisphosphonates have been launched on the market. The last drug available, zoledronic acid, the most potent of this drug family, can be administered intravenously. It possesses a long-acting efficacy, allowing a follow up on a yearly basis and permitting the chance of a very long remission of the Pagetic lesion. In the long term, prevention of severe complications can be envisaged, with a reasonable pharmacoeconomic cost. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|