Severe Encephalitis in Cynomolgus Macaques Exposed to Aerosolized Eastern Equine Encephalitis Virus
| Autor: | Cathleen M. Lind, Lawrence J. Sullivan, Matthew G. Lackemeyer, Sarah L. Norris, Jo Lynne Raymond, Douglas S. Reed, Scott Gamble, Nicole L. Garza |
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| Rok vydání: | 2007 |
| Předmět: |
Male
Time Factors Fever Eastern equine encephalitis virus Viremia Alphavirus Biology medicine.disease_cause Virus White blood cell medicine Animals Immunology and Allergy Leukocytosis Blood urea nitrogen Aerosols Encephalomyelitis Eastern Equine medicine.disease biology.organism_classification Virology Disease Models Animal Macaca fascicularis Infectious Diseases medicine.anatomical_structure Immunology Encephalitis Virus Eastern Equine Female medicine.symptom Encephalitis |
| Zdroj: | The Journal of Infectious Diseases. 196:441-450 |
| ISSN: | 1537-6613 0022-1899 |
| Popis: | Cynomolgus macaques exposed to an aerosol containing a virulent strain of eastern equine encephalitis (EEE) virus developed neurological signs indicating encephalitis that corresponded with the onset of fever and an elevated heart rate. Viremia was either transient or undetectable even in animals that succumbed to the illness. The onset of illness was dose dependent, but once a febrile response was observed, macaques were moribund within 36 h. Simultaneously, a prominent leukocytosis was seen; 1 day before being moribund, macaques had a white blood cell count >20,000 cells/ microL. The leukocytes were predominantly granulocytes. Increases in serum levels of blood urea nitrogen, sodium, and alkaline phosphatase were also seen. The rapid onset and severity of neurological signs mirror what has been reported for human cases of disease caused by EEE. |
| Databáze: | OpenAIRE |
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