| Autor: |
Zohreh Mirzapour Abbas abadi, Fatemeh Samiee Rad, Dariush Hamedi Asl, Babak Rahmani, Mahmood Soleimani Dodaran, Amir Peimani |
| Rok vydání: |
2021 |
| Zdroj: |
Iranian journal of pathology. 17(2) |
| ISSN: |
1735-5303 |
| Popis: |
Phosphatase and tensin homolog (PTEN) is a tumor suppressor gene located at chromosome 10. PTEN is a regulator of the PI3K/AKT signaling pathway that inhibits cell proliferation and promotes apoptosis. PTEN loss of function occurs in a spectrum of cancers, including colorectal adenocarcinoma. This study aimed to investigate the probable correlation of negative PTEN expression with clinicopathological features and colorectal adenocarcinoma (CRC) patients' survival.In this cross-sectional study using Immunohistochemistry stainingPTEN expression status on 151 CRC tissues was evaluated. Then the results of IHC staining was compared to those of clinicopathological features. The relationship between PTEN and KRAS mutation status was also investigated.Of 151 CRC samples, 89 (58.9%) were negative for PTEN expression. Loss of PTEN expression was associated with KRAS mutation (The current study suggests that decreasing PTEN expression or its negative expression may be associated with a higher stage and poor prognosis. Combined analysis of mutated KRAS and PTEN expression could be a good predictor of disease prognosis as well as its clinical outcomes. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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