Modelling the Human Placental Interface In Vitro-A Review
| Autor: | Kristina Haase, Marta Cherubini, Scott Erickson |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
maternal-fetal interface placenta microfluidics Disease Review Biology 03 medical and health sciences 0302 clinical medicine In vivo trophoblast invasion Placenta medicine TJ1-1570 Mechanical engineering and machinery Electrical and Electronic Engineering placenta-on-a-chip in vitro models Pregnancy Fetus 030219 obstetrics & reproductive medicine Mechanical Engineering Placental cell medicine.disease In vitro 030104 developmental biology medicine.anatomical_structure Control and Systems Engineering Neuroscience bioprinting Function (biology) |
| Zdroj: | Micromachines Micromachines, Vol 12, Iss 884, p 884 (2021) |
| ISSN: | 2072-666X |
| Popis: | Acting as the primary link between mother and fetus, the placenta is involved in regulating nutrient, oxygen, and waste exchange; thus, healthy placental development is crucial for a successful pregnancy. In line with the increasing demands of the fetus, the placenta evolves throughout pregnancy, making it a particularly difficult organ to study. Research into placental development and dysfunction poses a unique scientific challenge due to ethical constraints and the differences in morphology and function that exist between species. Recently, there have been increased efforts towards generating in vitro models of the human placenta. Advancements in the differentiation of human induced pluripotent stem cells (hiPSCs), microfluidics, and bioprinting have each contributed to the development of new models, which can be designed to closely match physiological in vivo conditions. By including relevant placental cell types and control over the microenvironment, these new in vitro models promise to reveal clues to the pathogenesis of placental dysfunction and facilitate drug testing across the maternal-fetal interface. In this minireview, we aim to highlight current in vitro placental models and their applications in the study of disease and discuss future avenues for these in vitro models. |
| Databáze: | OpenAIRE |
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