| Popis: |
Xueqin Yan,1,* Li Wang,1,* Xiaolan Chen,1 Anru Wang2 1Department of Child Health Care, Boai Hospital of Zhongshan Affiliated to Southern Medical University, Zhongshan, 528400, Peopleâs Republic of China; 2Department of Pediatrics, The Second of Affiliated Hospital of Nanjing Medical University, Nanjing, 210003, Peopleâs Republic of China*These authors contributed equally to this workCorrespondence: Anru Wang, Department of Pediatrics, The Second of Affiliated Hospital of Nanjing Medical University, No. 262 of Zhongshan North Road, Nanjing, 210003, Peopleâs Republic of China, Tel +86 25 83575027, Fax +86 25 58509975, Email wanganruwar8@126.com Xueqin Yan, Department of Child Health Care, Boai Hospital of Zhongshan Affiliated to Southern Medical University, No. 6 of Chenggui Road, Zhongshan, 528400, Peopleâs Republic of China, Tel +86 760-88776567, Fax +86 760-88306163, Email yanxueqin20032@126.comObjective: To explore the risk factors for neonatal congenital hypothyroidism (CH) and the influencing factors of false-positive results in CH screening.Methods: In this study, 255 neonatal patients with CH who completed the screening and further diagnosis and 366 neonates with positive CH screening results and normal thyroid function were selected as the case group. 246 healthy neonates with normal thyroid function were selected as the control group. Gestational age, birth-weight, maternal age, small for gestational age (SGA), perinatal factors (gestational thyroid dysfunction, gestational diabetes mellitus, etc.) were used as influencing factors, using Ï2 tests were performed for comparison. The statistically significant variables were analyzed with Logistic multiple regression models, and the difference was considered statistically significant (P< 0.05).Results: There were statistical differences in the SGA, maternal gestational diabetes mellitus, thyroid disease, and the proportion using assisted reproduction technology among the case group, false-positive screening group, and control group (Ï2 was 11.943, 6.857, 6.999, 9.732, respectively, P < 0.05). The results of multivariate logistic regression analysis showed that the gestational thyroid disease (OR = 8.452, 95% CI:1.051â 67.982), gestational diabetes mellitus (OR = 2.654, 95% CI:1.051â 6.706), and assisted reproduction (OR = 0.194, 95% CI:0.041â 0.911) were the influencing factors for neonatal CH, and the difference was statistically significant (P < 0.05). The SGA (OR = 2.556, 95% CI:1.027â 6.361), gestational thyroid disease (OR = 7.801, 95% CI:1.03â 59.057), gestational diabetes mellitus (OR = 2.731, 95% CI:1.18â 6.322), and assisted reproduction (OR = 0.28, 95% CI:0.102â 0.765) were the influencing factors of the false-positive screening results of neonatal CH. The difference was statistically significant (P < 0.05).Conclusion: Neonatal CH and positive screening results are influenced by assisted reproduction, gestational thyroid dysfunction, gestational diabetes mellitus, and SGA.Keywords: congenital hypothyroidism, false-positive, influencing factors, neonates |
