Evaluation of changes of serum hepatitis B surface antigen from a different perspective
| Autor: | Ting Liu, Zhiliang Gao, Ze-Qian Wu, Wei-Min Ke, Lei Tan |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Adult
Liver Cirrhosis Male HBsAg medicine.medical_specialty Hepatitis B virus Time Factors Adolescent Biopsy medicine.disease_cause Hepatitis b surface antigen Gastroenterology Severity of Illness Index Serology Young Adult Hepatitis B Chronic Predictive Value of Tests Retrospective Study Internal medicine medicine Humans Serologic Tests Hepatitis B e Antigens Aged Retrospective Studies Hepatitis B Surface Antigens medicine.diagnostic_test business.industry General Medicine Hepatitis B Middle Aged medicine.disease Liver Immunology Hepatic stellate cell Female sense organs Hepatic fibrosis business Biomarkers |
| Zdroj: | World journal of gastroenterology. 21(9) |
| ISSN: | 2219-2840 |
| Popis: | AIM: To investigate the dynamic changes of serum hepatitis B surface antigen (HBsAg) levels apportioned by the same hepatic parenchyma cell volume (HPCV), namely, hepatic cell quantities. METHODS: Serum HBsAg levels were detected by electrochemiluminescence and serum HBsAg levels apportioned by the same HPCV were figured out according to the theory of sphere geometry. HBsAg levels were compared among different liver inflammation grades, as well as different hepatic fibrosis stages. RESULTS: In hepatitis B e antigen-negative chronic hepatitis B, serum HBsAg levels in liver histological inflammation grades 1-4 were 3.66 ± 0.40, 3.74 ± 0.35, 3.74 ± 0.26 and 3.71 ± 0.34 log10 COI (cut off index), respectively, and there were no differences before apportion (P = 0.640). Serum HBsAg levels apportioned by the same HPCV were 5.57 ± 0.62, 5.98 ± 0.65, 6.59 ± 0.50 and 6.81 ± 0.84 log10 COI, respectively, and there were significant differences after apportion (P < 0.001). Serum HBsAg levels in hepatic fibrosis stages I-IV were 3.66 ± 0.43, 3.75 ± 0.33, 3.71 ± 0.28 and 3.75 ± 0.26 log10 COI, respectively, and there were no differences before apportion (P = 0.513). Serum HBsAg levels apportioned by the same HPCV were 5.53 ± 0.66, 5.98 ± 0.53, 6.29 ± 0.46 and 7.06 ± 0.48 log10 COI, respectively, and there were significant differences after apportion (P < 0.001). CONCLUSION: Serum HBsAg levels apportioned by the same HPCV (hepatic cell quantities), rather than serum HBsAg levels, increase with liver inflammation grades and hepatic fibrosis stages. |
| Databáze: | OpenAIRE |
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