An evaluation of the genotoxic potential of di-isononyl adipate
| Autor: | R. H. McKee, K. A. Traul, A. W. Lington |
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| Rok vydání: | 1986 |
| Předmět: |
endocrine system
Adipates Health Toxicology and Mutagenesis Hamster In Vitro Techniques Ames test Plasticizers Salmonella Cricetinae Adipate Genetics Animals Cells Cultured Carcinogen Mesocricetus biology Mutagenicity Tests biology.organism_classification Enterobacteriaceae In vitro Clone Cells Cell Transformation Neoplastic Biochemistry Microsome Mutagens |
| Zdroj: | Environmental Mutagenesis. 8:817-827 |
| ISSN: | 1930-238X 0192-2521 |
| Popis: | Di-isononyl adipate (DINA) is one of a group of adipates used primarily as plasticizers. Concern over the mutagenic and carcinogenic potential of these materials was stimulated by the finding that one member of this class, di-(2-ethylhexyl) adipate (DEHA), induced liver tumors in female mice in a chronic feeding study. Accordingly, the genotoxic potential of DINA was evaluated in a battery of in vitro tests including the Salmonella/mammalian microsome mutagenicity assay, the mouse lymphoma TK +/-assay, and two tests of morphologic transforming ability, the BALB 3T3 and the Syrian hamster embryo in vitro transformation assays. DINA did not exhibit any evidence of mutagenic or transforming potential in any of the assays utilized. |
| Databáze: | OpenAIRE |
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