Metabolic effects of supplementation with vitamin D in type 2 diabetic patients with vitamin D deficiency
| Autor: | José Manuel Ramiro-Lozano, José María Calvo-Romero |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Vitamin
Blood Glucose Male medicine.medical_specialty Endocrinology Diabetes and Metabolism medicine.medical_treatment 030209 endocrinology & metabolism 030204 cardiovascular system & hematology vitamin D deficiency 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Insulin resistance Internal medicine Diabetes mellitus Internal Medicine medicine Vitamin D and neurology Homeostasis Humans Insulin Vitamin D Aged Glycated Hemoglobin business.industry Type 2 Diabetes Mellitus General Medicine medicine.disease Vitamin D Deficiency Endocrinology chemistry Diabetes Mellitus Type 2 Dietary Supplements Calcifediol Female Insulin Resistance business |
| Zdroj: | Diabetesmetabolic syndrome. 10(2) |
| ISSN: | 1878-0334 |
| Popis: | Epidemiological studies suggest that vitamin D status influences type 2 diabetes mellitus. We investigate the metabolic effects of vitamin D.We studied consecutive type 2 diabetic patients without insulin therapy with vitamin D deficiency (serum 25-hydroxyvitamin D (25(OH)D) lower than 20ng/ml). They were treated with 16,000IU of calcifediol orally once a week for a minimum of 8 weeks.Twenty eight patients were treated for a mean time of 84.1 days (range 56 to 120 days). All patients achieved serum levels of 25(OH)D higher than 20ng/ml. There was a significant reduction in fasting glucose (145.6±35.5 vs. 131.7±30.4mg/dl, p0.001). There were small non-significant reductions in HbA1c, fasting insulin and Homeostasis Model Assesment (HOMA)-insulin resistance (IR). There were small non-significant increases in HOMA-insulin sensitivity (S) and HOMA-beta cell function (B) and a small significant increase in Quantitative Insulin Sensitivity Check Index (QUICKI).Correction of vitamin D deficiency in type 2 diabetic patients decreases fasting glucose. Our results do not rule out improvements in metabolic control, insulin-resistance and function of the beta cell. |
| Databáze: | OpenAIRE |
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