Sclerosing Epithelioid Fibrosarcoma of the Pituitary
| Autor: | Christopher Clark, Luis A. Llerena, Bernd W. Scheithauer, Anamaria Massier, Harris C. Taylor |
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| Rok vydání: | 2007 |
| Předmět: |
Pathology
medicine.medical_specialty Fibrosarcoma Endocrinology Diabetes and Metabolism medicine.medical_treatment Vimentin Pituitary neoplasm Radiosurgery Pathology and Forensic Medicine Diagnosis Differential Endocrinology Immunophenotyping medicine Humans Pituitary Neoplasms Venous Thrombosis integumentary system biology business.industry Arthritis Estrogen Replacement Therapy Soft Tissue Fibrosarcoma General Medicine Middle Aged medicine.disease Magnetic Resonance Imaging Radiation therapy Hypertension biology.protein Osteoporosis Female Sarcoma Neoplasm Recurrence Local Differential diagnosis business |
| Zdroj: | Endocrine Pathology. 18:233-238 |
| ISSN: | 1559-0097 1046-3976 |
| DOI: | 10.1007/s12022-007-9010-2 |
| Popis: | Primary pituitary sarcoma in the absence of previous radiation therapy is very rare, only eight cases having been reported. We present the first reported case of sclerosing epithelioid fibrosarcoma of the pituitary, a 56-year-old woman presenting with diplopia and panhypopituitarism. Magnetic resonance imaging showed a 1.2 x 0.4 x 0.5-cm sellar mass invading the right cavernous sinus. Despite surgery and radiation therapy, our patient developed intracranial metastases and died 2 years after the initial diagnosis. Sclerosing epithelioid fibrosarcoma is an infrequently occurring, distinct variant of soft tissue fibrosarcoma. Its immunophenotype includes vimentin and occasionally CD-34, B cell lymphoma-2, S-100 protein, or keratin expression. Although initially thought to be a low-grade lesion, sclerosing epithelioid fibrosarcomas may also behave in a high-grade manner. |
| Databáze: | OpenAIRE |
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