Glutathione S-transferase expression in the human testis and testicular germ cell neoplasia
| Autor: | D. J. Harrison, G. Howard, H. S. Klys, D. Whillis |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 1992 |
| Předmět: |
Adult
Male Cancer Research medicine.medical_specialty endocrine system endocrine system diseases Adolescent Dysgerminoma Testicle Testicular Neoplasms Internal medicine Cryptorchidism Testis medicine Mesonephroma Humans Glutathione Transferase biology Intratubular germ cell neoplasia Seminoma Middle Aged Neoplasms Germ Cell and Embryonal medicine.disease Sertoli cell medicine.anatomical_structure Endocrinology Glutathione S-transferase Oncology biology.protein Cancer research Teratoma Germ cell Research Article |
| Zdroj: | British Journal of Cancer |
| ISSN: | 1532-1827 0007-0920 |
| Popis: | Glutathione S-transferase (GST) isoenzyme expression is altered in a variety of neoplasms and the enzymes are implicated in metabolism of carcinogens and resistance to drugs, including cisplatin. We have studied GST Alpha, Pi, Mu and microsomal isoenzyme expression by immunohistochemistry in normal and cryptorchid testes, intratubal germ cell neoplasia (ITGCN), seminoma and non-seminomatous germ cell tumours. In 16 stage II-IV malignant teratoma intermediate (MTI) both orchidectomy and post-treatment residual surgical masses were studied. All four isoenzymes were strongly expressed in Leydig and Sertoli cells. GST Pi was absent from normal spermatogonia but strongly expressed by the neoplastic germ cells of ITGCN and seminoma. GST Pi was strongly expressed in all elements of teratoma, irrespective of differentiation. There were no qualitative differences in expression between primary and post-chemotherapy metastases. GST Alpha expression in teratoma correlated with epithelial differentiation. GSTs may be important in normal spermatogenesis and protection of germ cells from teratogens and carcinogens. They may have a role in testicular tumour drug resistance but this role is not well defined. GST Pi is a new marker for ITGCN. Images Figure 1 Figure 2 Figure 3 Figure 4 Figure 5 Figure 6 |
| Databáze: | OpenAIRE |
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