A comparative clinical trial of duodenal ulcer healing with two regimens of cimetidine: 800 mg once nightly and 400 mg twice daily
| Autor: | A. Nikopoulos, A. Theoharidis, Constantine Arvanitakis, E. Giannoulis, Achilleas Tourkantonis |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Adult
Male medicine.medical_treatment 030204 cardiovascular system & hematology Biochemistry Drug Administration Schedule law.invention 03 medical and health sciences 0302 clinical medicine Histamine H2 receptor Randomized controlled trial law Medicine Humans Cimetidine Adverse effect Duodenoscopy Chemotherapy business.industry Biochemistry (medical) Cell Biology General Medicine Middle Aged Clinical trial Regimen medicine.anatomical_structure 030220 oncology & carcinogenesis Anesthesia Duodenal Ulcer Duodenum Female business medicine.drug |
| Zdroj: | The Journal of international medical research. 18(5) |
| ISSN: | 0300-0605 |
| Popis: | The efficacy and safety of two dosage regimens of cimetidine were compared in a single-blind study of 50 adults with endoscopically proven duodenal ulcers. Patients were randomly allocated to receive 800 mg cimetidine taken once nightly or 400 mg cimetidine taken twice daily for 4 weeks. Following 4 weeks' treatment patients again underwent endoscopy and, if healing was incomplete, they received a further 4 weeks' treatment. At 4 weeks, healing occurred in 21/25 (84%) patients on the once-daily regimen and in 15/25 (60%) patients treated twice daily ( P < 0.05). Cumulative healing rates after 8 weeks' treatment were 92% and 96%, respectively. Symptomatic improvement was obtained to the same degree with both regimens. No adverse effects were recorded and laboratory values remained normal during both treatments. The results indicate that cimetidine given as one dose each night was superior to the twice-daily regimen. |
| Databáze: | OpenAIRE |
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