Short-term effects of the DASH diet in adults with moderate chronic kidney disease: a pilot feeding study
| Autor: | Leonor Corsino, Huiman X. Barnhart, Bryan C. Batch, Laura P. Svetkey, Shelly Sapp, Chinazo Nwankwo, Jenifer Allen, Pao-Hwa Lin, Jasmine Burroughs, Crystal C. Tyson |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
DASH diet Hyperkalemia kidney disease 030232 urology & nephrology Renal function 030204 cardiovascular system & hematology 03 medical and health sciences 0302 clinical medicine Internal medicine Dash Chronic Kidney Disease medicine 2. Zero hunger Transplantation business.industry blood pressure Metabolic acidosis medicine.disease 3. Good health Endocrinology Blood pressure Nephrology Serum electrolytes medicine.symptom business human activities Kidney disease metabolic side effects |
| Zdroj: | Clinical Kidney Journal |
| ISSN: | 2048-8513 2048-8505 |
| Popis: | Background Although the Dietary Approaches to Stop Hypertension (DASH) diet lowers blood pressure (BP) for adults with normal kidney function, evidence is lacking regarding its safety and efficacy in chronic kidney disease (CKD). We aimed to test the effects of the DASH diet on serum electrolytes and BP in adults with moderate CKD. Methods In a prospective before–after feeding study, 11 adults with an estimated glomerular filtration rate of 30–59 mL/min/1.73 m2 and medication-treated hypertension were provided a reduced-sodium, run-in diet for 1 week followed by a reduced-sodium, DASH diet for 2 weeks. Changes in serum electrolytes and BP were compared pre–post DASH. Results Eleven participants underwent feeding; 1 completed 1 week and 10 completed 2 weeks of DASH. Compared with baseline, DASH modestly increased serum potassium at 1 week (mean ± standard deviation, +0.28 ± 0.4 mg/dL; P = 0.043) but had no significant effect on potassium at 2 weeks (+0.15 ± 0.28 mg/dL; P = 0.13). Serum bicarbonate was reduced (−2.5 ± 3.0 mg/dL; P = 0.03) at 2 weeks. Neither incident hyperkalemia nor new onset metabolic acidosis was observed. Clinic BP and mean 24-h ambulatory BP was unchanged. DASH significantly reduced mean nighttime BP (−5.3 ± 5.8 mmHg; P = 0.018), and enhanced percent declines in both nocturnal systolic BP (−2.1% to −5.1%; P = 0.004) and diastolic BP (−3.7% to −10.0%; P = 0.008). Conclusions These pilot data suggest that a reduced-sodium DASH dietary pattern does not cause acute metabolic events in adults with moderate CKD and may improve nocturnal BP. Definitive studies are needed to determine long-term effects of DASH in CKD. |
| Databáze: | OpenAIRE |
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