| Přispěvatelé: |
The ESBL-REIPI group, [Rodríguez-Baño,J, Serrano,L, López-Cerero, Lorena, Pascual,A] Unidad Clínica de Enfermedades Infecciosas y Microbiología, Hospital Universitario Virgen Macarena, Sevilla, Spain. [Rodríguez-Baño,J] Servicio de Microbiología, Hospital Universitario La Paz - IdiPAZ, Madrid, Spain. [Mingorance,J, Fernández-Romero,N] Departamento de Medicina, Universidad de Sevilla, Sevilla, Spain. [Pascual,A] Departamento de Microbiología, Universidad de Sevilla, Sevilla, Spain., This study was funded by the Ministerio de Ciencia e Innovación, Instituto de Salud Carlos III - co-financed by European Development Regional Fund ‘‘A way to achieve Europe’’ ERDF, Spanish Network for Research in Infectious Diseases (REIPI RD06/0008), Fondo de Investigación Sanitaria (grants 070190, 10/02021,10/01955, and 10/00795), and Junta de Andalucía (grants 0048/2008, and CTS-5259)., Universidad de Sevilla. Departamento de Microbiología, Universidad de Sevilla. Departamento de Medicina |
| Popis: |
There is scarce data about the importance of phylogroups and virulence factors (VF) in bloodstream infections (BSI) caused by extended-spectrum β-lactamase-producing Escherichia coli (ESBLEC). A prospective multicenter Spanish cohort including 191 cases of BSI due to ESBLEC was studied. Phylogroups and 25 VF genes were investigated by PCR. ESBLEC were classified into clusters according to their virulence profiles. The association of phylogropus, VF, and clusters with epidemiological features were studied using multivariate analysis. Overall, 57.6%, 26.7%, and 15.7% of isolates belonged to A/B1, D and B2 phylogroups, respectively. By multivariate analysis (adjusted OR [95% CI]), virulence cluster C2 was independently associated with urinary tract source (5.05 [0.96-25.48]); cluster C4 with sources other than urinary of biliary tract (2.89 [1.05-7.93]), and cluster C5 with BSI in non-predisposed patients (2.80 [0.99-7.93]). Isolates producing CTX-M-9 group ESBLs and from phylogroup D predominated among cluster C2 and C5, while CTX-M-1 group of ESBL and phylogroup B2 predominantes among C4 isolates. These results suggest that host factors and previous antimicrobial use were more important than phylogroup or specific VF in the occurrence of BSI due to ESBLEC. However, some associations between virulence clusters and some specific epidemiological features were found Spanish Network for Research in Infectious Diseases REIPI RD06/0008 Fondo de Investigación Sanitaria 070190, 10/02021, 10/01955, y 10/00795 Junta de Andalucía 0048/2008 y CTS-5259 |
