Risk factors for atherosclerotic and medial arterial calcification of the intracranial internal carotid artery

Autor: Mayken Visser, Frederick J. A. Meijer, Diederik W.J. Dippel, M.J.H. Wermer, Jeannette Hofmeijer, Pim A. de Jong, Irene C. van der Schaaf, Jelis Boiten, Y. van der Graaf, W.J. van Rooij, K.E. Droogh-de Greve, S. L. M. Bakker, Yvonne T. van der Schouw, B.K. Velthuis, Willem P.Th.M. Mali, C. Constantijn Pleiter, T. van Seeters, Geert Jan Biessels, P.L.M. de Kort, W. P. T. M. Mali, G. J. Lycklama à Nijeholt, Yvo B.W.E.M. Roos, Joris M. Niesten, Jan Albert Vos, Koos Keizer, Jill B. De Vis, Merel J A Luitse, Charles B. L. M. Majoie, E.J. van Dijk, L.E. Duijm, Remko Kockelkoren, M.A.A. van Walderveen, F.O. Kesselring, Birgitta K. Velthuis, J.W. Dankbaar, I.C. van der Schaaf, Annelotte Vos, Henri Paul Bienfait, Vincent I H Kwa, Wouter J. Schonewille, Alexander D. Horsch, D.A. Duyndam, L. J. Kappelle, A. van der Lugt
Přispěvatelé: ACS - Microcirculation, Radiology and Nuclear Medicine, ANS - Neurovascular Disorders, ACS - Atherosclerosis & ischemic syndromes, Neurology, Radiology & Nuclear Medicine, Radiology and nuclear medicine, Amsterdam Neuroscience - Neurovascular Disorders, VU University medical center, Division 1
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Adult
Carotid Artery Diseases
Male
medicine.medical_specialty
Computed Tomography Angiography
030204 cardiovascular system & hematology
Cardiovascular disease risk factors
Risk Assessment
03 medical and health sciences
0302 clinical medicine
Risk Factors
medicine.artery
Internal medicine
Diabetes mellitus
Multidetector Computed Tomography
medicine
Humans
Risk factor
Vascular Calcification
Stroke
Aged
Netherlands
Aged
80 and over
Medial arterial calcification
Vascular disease
business.industry
Middle Aged
Intracranial Arteriosclerosis
medicine.disease
Atherosclerosis
Cerebral Angiography
Pulse pressure
Cross-Sectional Studies
Cardiology
Female
Internal carotid artery
Tunica Intima
Tunica Media
Cardiology and Cardiovascular Medicine
business
Intracranial carotid artery
Carotid Artery
Internal
030217 neurology & neurosurgery
Calcification
Zdroj: Atherosclerosis, 276, 44-49. Elsevier Ireland Ltd
Vos, A, Kockelkoren, R, de Vis, J B, van der Schouw, Y T, van der Schaaf, I C, Velthuis, B K, Mali, W P T M, de Jong, P A & the DUST study group 2018, ' Risk factors for atherosclerotic and medial arterial calcification of the intracranial internal carotid artery ', Atherosclerosis, vol. 276, pp. 44-49 . https://doi.org/10.1016/j.atherosclerosis.2018.07.008
Atherosclerosis, 276, 44. Elsevier
Atherosclerosis, 276, 44-49
ISSN: 0021-9150
DOI: 10.1016/j.atherosclerosis.2018.07.008
Popis: Background and aims Calcifications of the intracranial internal carotid artery (iICA) are an important risk factor for stroke. The calcifications can occur both in the intimal and medial layer of the vascular wall. The aim of this study is to assess whether medial calcification in the iICA is differently related to risk factors for cardiovascular disease, compared to intimal calcification. Methods Unenhanced thin slice computed tomography (CT) scans from 1132 patients from the Dutch acute stroke study cohort were assessed for dominant localization of calcification (medial or intimal) by one of three observers based on established methodology. Associations between known cardiovascular risk factors (age, gender, body mass index, pulse pressure, eGFR, smoking, hypertension, diabetes mellitus, hyperlipidemia, previous vascular disease, and family history) and the dominant localization of calcifications were assessed via logistic regression analysis. Results In the 1132 patients (57% males, mean age 67.4 years [SD 13.8]), dominant intimal calcification was present in 30.9% and dominant medial calcification in 46.9%. In 10.5%, no calcification was seen. Age, pulse pressure and family history were risk factors for both types of calcification. Multivariably adjusted risk factors for dominant intimal calcification only were smoking (OR 2.09 [CI 1.27–3.44]) and hypertension (OR 2.09 [CI 1.29–3.40]) and for dominant medial calcification diabetes mellitus (OR 2.39 [CI 1.11–5.14]) and previous vascular disease (OR 2.20 [CI 1.30–3.75]). Conclusions Risk factors are differently related to the dominant localizations of calcifications, a finding that supports the hypothesis that the intimal and medial calcification represents a distinct etiology.
Databáze: OpenAIRE
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