Peptide YY (PYY) Is Associated with Cardiovascular Risk in Patients with Acute Myocardial Infarction
| Autor: | Evangelos Giannitsis, Marcia Viviane Rückbeil, Mohammad Almalla, Moritz Biener, Nikolaus Marx, J. Schroeder, Julia Moellmann, Florian Kahles, Michael Lehrke, Elias Haj-Yehia, Matthias Rau, R W Mertens, Hugo A. Katus |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
cardiovascular risk
medicine.medical_specialty Renal function lcsh:Medicine 030209 endocrinology & metabolism Disease 030204 cardiovascular system & hematology Article 03 medical and health sciences 0302 clinical medicine Diabetes mellitus Internal medicine Medicine Myocardial infarction cardiovascular diseases PYY business.industry Proportional hazards model Confounding digestive oral and skin physiology lcsh:R General Medicine medicine.disease mortality myocardial infarction Peptide YY Heart failure Cardiology business hormones hormone substitutes and hormone antagonists gut hormone |
| Zdroj: | Journal of Clinical Medicine, Vol 9, Iss 3952, p 3952 (2020) Journal of Clinical Medicine Volume 9 Issue 12 |
| ISSN: | 2077-0383 |
| Popis: | Aims: Recent studies have found circulating concentrations of the gastrointestinal hormone GLP-1 to be an excellent predictor of cardiovascular risk in patients with myocardial infarction. This illustrates a yet not appreciated crosstalk between the gastrointestinal and cardiovascular systems, which requires further investigation. The gut-derived hormone Peptide YY (PYY) is secreted from the same intestinal L-cells as GLP-1. Relevance of PYY in the context of cardiovascular disease has not been explored. In this study, we aimed to investigate PYY serum concentrations in patients with acute myocardial infarction and to evaluate their association with cardiovascular events. Material and Methods: PYY levels were assessed in 834 patients presenting with acute myocardial infarction (553 Non-ST-Elevation Myocardial Infarction (NSTEMI) and 281 ST-Elevation Myocardial Infarction (STEMI)) at the time of hospital admission. The composite outcomes of first occurrence of cardiovascular death, nonfatal myocardial infarction, nonfatal stroke (3-P-MACE), and all-cause mortality were assessed with a median follow-up of 338 days. Results: PYY levels were significantly associated with age and cardiovascular risk factors, including hypertension, diabetes, and kidney function in addition to biomarkers of heart failure (NT-pro BNP) and inflammation (hs-CRP). Further, PYY was significantly associated with 3-P-MACE (HR: 1.7 95% CI: 1&ndash 2.97 p = 0.0495) and all-cause mortality (HR: 2.69 95% CI: 1.61&ndash 4.47 p = 0.0001) by univariable Cox regression analyses, which was however lost after adjusting for multiple confounders. Conclusions: PYY levels are associated with parameters of cardiovascular risk as well as cardiovascular events and mortality in patients presenting with acute myocardial infarction. However, this significant association is lost after adjustment for further confounders. |
| Databáze: | OpenAIRE |
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