Childhood physical, environmental, and genetic predictors of adult hypertension: the cardiovascular risk in young Finns study
| Autor: | Costan G. Magnussen, Tomi Laitinen, Vera Mikkilä, Leena Taittonen, Olli T. Raitakari, Niina Siitonen, Jonna Juhola, Peter Würtz, Jorma S. A. Viikari, Eero Jokinen, Mika Kähönen, Ilkka Seppälä, Nina Hutri-Kähönen, Markus Juonala, Samuel S. Gidding, Antti Jula, Terho Lehtimäki, Mervi Oikonen |
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| Rok vydání: | 2012 |
| Předmět: |
Adult
Male Pediatrics medicine.medical_specialty Longitudinal study Blood Pressure Polymorphism Single Nucleotide Risk Assessment Cohort Studies Predictive Value of Tests Risk Factors Physiology (medical) medicine Humans Longitudinal Studies Obesity Prospective Studies Risk factor Prospective cohort study Finland business.industry Age Factors ta3121 Middle Aged Overweight Pedigree Blood pressure Social Class Cardiovascular Diseases Predictive value of tests Cohort Hypertension Female Cardiology and Cardiovascular Medicine business Risk assessment Cohort study Follow-Up Studies |
| Zdroj: | Circulation. 126(4) |
| ISSN: | 1524-4539 |
| Popis: | Background— Hypertension is a major modifiable cardiovascular risk factor. The present longitudinal study aimed to examine the best combination of childhood physical and environmental factors to predict adult hypertension and furthermore whether newly identified genetic variants for blood pressure increase the prediction of adult hypertension. Methods and Results— The study cohort included 2625 individuals from the Cardiovascular Risk in Young Finns Study who were followed up for 21 to 27 years since baseline (1980; age, 3–18 years). In addition to dietary factors and biomarkers related to blood pressure, we examined whether a genetic risk score based on 29 newly identified single-nucleotide polymorphisms enhances the prediction of adult hypertension. Hypertension in adulthood was defined as systolic blood pressure ≥130 mm Hg and/or diastolic blood pressure ≥85 mm Hg or medication for the condition. Independent childhood risk factors for adult hypertension included the individual's own blood pressure ( P P P =0.005), low parental occupational status ( P =0.003), and high genetic risk score ( P P =0.0007). Inclusion of both parental hypertension history and data on novel genetic variants for hypertension further improved the C statistics (0.742; P =0.015). Conclusions— Prediction of adult hypertension was enhanced by taking into account known physical and environmental childhood risk factors, family history of hypertension, and novel genetic variants. A multifactorial approach may be useful in identifying children at high risk for adult hypertension. |
| Databáze: | OpenAIRE |
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