Low-Dose Aspirin Use Significantly Improves the Survival of Late-stage NPC: A Propensity Score-Matched Cohort Study in Taiwan
| Autor: | Sheng-Dean Luo, Wei-Chih Chen, Yao-Hsu Yang, Ching-Nung Wu, Tai-Jan Chiu, Fu-Min Fang, Shau-Hsuan Li, Yu-Ming Wang, Tai-Lin Huang, Shao-Chun Wu |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Oncology
Cancer Research medicine.medical_specialty low-dose aspirin overall survival rate lcsh:RC254-282 Article disease-specific survival rate 03 medical and health sciences 0302 clinical medicine Internal medicine medicine otorhinolaryngologic diseases 030212 general & internal medicine Survival rate Aspirin Proportional hazards model business.industry nasopharyngeal carcinoma Retrospective cohort study medicine.disease lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens stomatognathic diseases Disease-specific Survival Rate Nasopharyngeal carcinoma 030220 oncology & carcinogenesis Propensity score matching 10-year follow-up time business Low dose aspirin medicine.drug |
| Zdroj: | Cancers, Vol 12, Iss 1551, p 1551 (2020) Cancers Volume 12 Issue 6 |
| ISSN: | 2072-6694 |
| Popis: | Background: Aspirin use has been associated with improved survival rates in various cancers. However, it remains unclear if aspirin confers a survival benefit on patients with nasopharyngeal carcinoma (NPC). The aim of this study was to assess the associations between aspirin use and survival in different stages of NPC. Methods: This is a 10-year retrospective cohort study of NPC patients. A total of 565 NPC patients were recruited after we performed a 1:4 propensity score match between aspirin users and non&ndash users. Cox regression models with adjusted covariates were employed to evaluate factors that influence the survival rate of NPC patients. Results: The Kaplan-Meier analysis revealed that the overall survival (p < 0.0001) and disease-specific survival (p < 0.0001) rates of 180-day aspirin users increased. Increased survival rates were also observed in 180-day aspirin users with Stages III and IV, T, N1 and 2, and N3 categories. Cox regression models indicated that factors, including aspirin use (univariate: HR = 0.28, 95% CI = 0.14&ndash 0.55, p < 0.001 multivariate: HR = 0.23, 95% CI = 0.12&ndash 0.46, p < 0.001), were independent prognostic factors for survival. Conclusions: Aspirin use for more than 180 days is associated with an increased survival rate and is a positive independent prognostic factor in NPC. |
| Databáze: | OpenAIRE |
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