Modulatory effect of alpha2 adrenoceptor agonists on Ro 5-4864-induced convulsions in rats and mice
| Autor: | Shrinivas K. Kulkarni, J. Kunchandy |
|---|---|
| Rok vydání: | 1987 |
| Předmět: |
Male
medicine.medical_specialty medicine.medical_treatment Convulsants Mice Inbred Strains Pharmacology Guanidines Clonidine Mice Seizures Internal medicine Convulsion medicine Animals Injections Intraventricular Phenylacetates Benzodiazepinones Chemistry Imidazoles Brain Rats Inbred Strains Azepines Receptors Adrenergic alpha Receptors GABA-A Guanfacine Rats Yohimbine Anticonvulsant Endocrinology Anticonvulsants Alpha-2 adrenergic receptor medicine.symptom Idazoxan Diazepam medicine.drug |
| Zdroj: | Psychopharmacology. 93:113-117 |
| ISSN: | 1432-2072 0033-3158 |
| DOI: | 10.1007/bf02439596 |
| Popis: | The protective effect of various alpha 2 adrenoceptor agonists such as clonidine, guanfacine, B-HT 920 and ICI 106270 was investigated against Ro 5-4864-induced convulsions in mice and rats. Clonidine and ICI 106270 exhibited a profound anticonvulsant effect while equivalent doses of guanfacine and B-HT 920 were less effective. The anticonvulsant effect of clonidine and ICI 106270 was reversed by pretreatment with yohimbine or idazoxan, indicating the involvement of alpha 2 adrenoceptors in their protective effect. Diazepam, clonazepam, CL 218, 872 and pentobarbitone exhibited a different profile of protective action, as these agents protected the animals from apparent mortality as compared to clonidine and ICI 106270 which prolonged the latencies of jerk and convulsion. Modulatory effects of alpha 2 adrenoceptors in central GABA function and multiple sites for Ro 5-4864-induced seizures are explained. |
| Databáze: | OpenAIRE |
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