Telomerase Reverse Transcriptase Delays Aging in Cancer-Resistant Mice
| Autor: | Ander Matheu, Peter Klatt, Consuelo Borrás, Jose Viña, Manuel Serrano, Agueda M. Tejera, Pablo J. Fernandez-Marcos, Ignacio Flores, Maria A. Blasco, María L. Cayuela, Antonia Tomás-Loba, Antonio Maraver, Juana M. Flores |
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| Rok vydání: | 2008 |
| Předmět: |
Keratinocytes
Aging Telomerase Cell Survival Transgene HUMDISEASE Mice Transgenic Context (language use) Biology Models Biological Gene Expression Regulation Enzymologic General Biochemistry Genetics and Molecular Biology Mice Neoplasms medicine Animals Humans Telomerase reverse transcriptase Viability assay Insulin-Like Growth Factor I Regulation of gene expression Biochemistry Genetics and Molecular Biology(all) Stem Cells Cancer medicine.disease Molecular biology Telomere Gene Expression Regulation Neoplastic Cancer research CELLBIO Epidermis |
| Zdroj: | Cell. 135(4):609-622 |
| ISSN: | 0092-8674 |
| DOI: | 10.1016/j.cell.2008.09.034 |
| Popis: | Summary Telomerase confers limitless proliferative potential to most human cells through its ability to elongate telomeres, the natural ends of chromosomes, which otherwise would undergo progressive attrition and eventually compromise cell viability. However, the role of telomerase in organismal aging has remained unaddressed, in part because of the cancer-promoting activity of telomerase. To circumvent this problem, we have constitutively expressed telomerase reverse transcriptase (TERT), one of the components of telomerase, in mice engineered to be cancer resistant by means of enhanced expression of the tumor suppressors p53, p16, and p19ARF. In this context, TERT overexpression improves the fitness of epithelial barriers, particularly the skin and the intestine, and produces a systemic delay in aging accompanied by extension of the median life span. These results demonstrate that constitutive expression of Tert provides antiaging activity in the context of a mammalian organism. |
| Databáze: | OpenAIRE |
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