DNA-dependent protein kinase : effect on DSB repair, G2/M checkpoint and mode of cell death in NSCLC cell lines

Autor:	Michael Groneberg, Ali Sak, Martin Stuschke
Jazyk:	angličtina
Rok vydání:	2019
Předmět:	Programmed cell death Lung Neoplasms DNA Repair Morpholines Medizin Mitosis DNA-Dependent Protein Kinase Apoptosis DNA-Activated Protein Kinase 030218 nuclear medicine & medical imaging Histones 03 medical and health sciences 0302 clinical medicine Radiation sensitivity G2/M checkpoint Carcinoma Non-Small-Cell Lung Cell Line Tumor Dsb repair Humans DNA Breaks Double-Stranded Radiology Nuclear Medicine and imaging Protein Kinase Inhibitors Mitotic catastrophe Radiological and Ultrasound Technology Chemistry Cell cycle G2 Phase Cell Cycle Checkpoints enzymes and coenzymes (carbohydrates) Chromones 030220 oncology & carcinogenesis Cancer research M Phase Cell Cycle Checkpoints Tumor Suppressor Protein p53 biological phenomena cell phenomena and immunity Signal Transduction
Popis:	Purpose: To evaluate the effect of NU7026, a specific inhibitor of DNA-PKcs, on DNA-double strand break (DSB) repair in a cell cycle specific manner, on the G2/M checkpoint, mitotic progression, ap...
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::096f374789abd6e1a4b85f0e7c768097 https://www.ncbi.nlm.nih.gov/pubmed/31287365 Zobrazit plný text záznamu